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BRK inhibitor P21d hydrochloride 

Cat. No.: HY-115514A
Handling Instructions

BRK inhibitor P21d hydrochloride is a potent breast tumor kinase (BRK/PTK6) inhibitor with an IC50 of 30 nM. BRK inhibitor P21d hydrochloride inhibits p-SAM68 with an IC50 of 52 nM. BRK inhibitor P21d hydrochloride can be used to evaluate the in vivo activity of BRK inhibitors in xenograft breast tumor models.

For research use only. We do not sell to patients.

BRK inhibitor P21d hydrochloride Chemical Structure

BRK inhibitor P21d hydrochloride Chemical Structure

CAS No. : 2250025-98-8

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Description

BRK inhibitor P21d hydrochloride is a potent breast tumor kinase (BRK/PTK6) inhibitor with an IC50 of 30 nM. BRK inhibitor P21d hydrochloride inhibits p-SAM68 with an IC50 of 52 nM. BRK inhibitor P21d hydrochloride can be used to evaluate the in vivo activity of BRK inhibitors in xenograft breast tumor models[1].

IC50 & Target

IC50: 30 nM (BRK), 52 nM (p-SAM68), >20 μM (Aurora B), >20 μM (Lck)[1]

In Vitro

BRK inhibitor P21d hydrochloride (compound 21d) inhibits Aurora B (IC50>20 μM) and Lck (IC50>20 μM)[1].

In Vivo

BRK inhibitor P21d hydrochloride (compound 21d) has much better permeability (CACO-2:314 nm/s) and PK profile (rat, po, 10 mpk, AUC0–6h=31.1 μM•h,C6h=3.5 μM)[1].

Molecular Weight

483.93

Formula

C₂₃H₂₃ClFN₇O₂

CAS No.

2250025-98-8

SMILES

O=C(C1=CC=C(NC2=NC(C3CC3)=CN4C2=NC=C4C5=CNN=C5)C(F)=C1)N6CCOCC6.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BRK inhibitor P21dOthersbreasttumorkinaseBRKPTK6p-SAM68Inhibitorinhibitorinhibit

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BRK inhibitor P21d hydrochloride
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HY-115514A
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