2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. BRK
  5. BRK Inhibitor

BRK Inhibitor

BRK Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-108333
    SB-633825
    		Inhibitor 98.52%
    SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis.
  • HY-110244
    Tilfrinib
    		Inhibitor 99.69%
    Tilfrinib (compound 4f) is a potent and selective Brk/PTK6 inhibitor with an IC50 value of 3.15 nM for Brk. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour.
  • HY-115514A
    BRK inhibitor P21d hydrochloride
    		Inhibitor ≥98.0%
    BRK inhibitor P21d hydrochloride is a potent breast tumor kinase (BRK/PTK6) inhibitor with an IC50 of 30 nM. BRK inhibitor P21d hydrochloride inhibits p-SAM68 with an IC50 of 52 nM. BRK inhibitor P21d hydrochloride can be used to evaluate the in vivo activity of BRK inhibitors in xenograft breast tumor models.