1600515-49-8
1600515-49-8
Chemical Structure
Tilfrinib
- CAS. Nr.: 1600515-49-8
- Formula:C17H13N3O
- Molecular Weight:275.30
IUPAC Name: 3-((9H-pyrido[2,3-b]indol-4-yl)amino)phenol
InChIKey: RXPZOSHFGJWSLQ-UHFFFAOYSA-N
SMILES: OC1=CC=CC(NC2=C3C4=CC=CC=C4NC3=NC=C2)=C1
Biological Activity: Tilfrinib (compound 4f) is a potent and selective Brk/PTK6 inhibitor with an IC50 value of 3.15 nM for Brk. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Tilfrinib | 99.39% | Tilfrinib (compound 4f) is a potent and selective Brk/PTK6 inhibitor with an IC50 value of 3.15 nM for Brk. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour. | ||||||||||||||||||||
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Tilfrinib (Standard) | ≥98% | Tilfrinib (Standard) is the analytical standard of Tilfrinib (HY-110244). This product is intended for research and analytical applications. Tilfrinib (compound 4f) is a potent and selective Brk/PTK6 inhibitor with an IC50 value of 3.15 nM for Brk. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour. | ||||||||||||||||||||
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References
- [1]. Zhang Q, Liu S, et al. ETV4 mediated tumor-associated neutrophil recruitment promotes lymphangiogenesis and lymphatic metastasis of bladder cancer[J]. 2022.
- [2]. Mahmoud KA, et al. Discovery of 4-anilino α-carbolines as novel Brk inhibitors. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1948-51. [Content Brief]
