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Cat. No.: HY-178479

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IDO1-IN-30

IDO1-IN-30 (Compound (R)-100) is a potent and highly selective IDO1 inhibitor. IDO1-IN-30 has an IC₅₀ of 4.8 nM to IDO1 in SKOV3 cells. IDO1-IN-30 does not show significant cytotoxicity at 25 µM in HepG2 cells. IDO1-IN-30 can eliminate inhibition of CYP450 enzymes (such as 3A4, 2C9, 2D6). IDO1-IN-30 can be used for research on cancer and inflammatory conditions.

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CAS No.: 2581050-29-3
Formule: C₁₉H₁₆F₂N₆O₂
Masse moléculaire:398.37

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

IDO1-IN-30 Chemical Structure

CAS No.: 2581050-29-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Indoleamine 2,3-Dioxygenase (IDO) :

Voir tous les produits spécifiques à Isoform Cytochrome P450 :

Chemical Information

CAS No. 2581050-29-3
Masse moléculaire 398.37
Formule C₁₉H₁₆F₂N₆O₂
SMILES

FC1=C(OC)C=C(F)C(N2N=NC([C@H](O)C3=C(N=CC4=CN=CN34)C5CC5)=C2)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Cren S, et al. Cellular Potency Optimization of Novel Heme-Binding Imidazo[5,1-b]thiazoles, Imidazo[1,5-a]pyridines and Pyrazines as Potent IDO1 Inhibitors Devoid of Cytochrome P450 Inhibition. J Med Chem. 2025 Oct 9;68(19):20130-20153. [Content Brief]

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Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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IDO1-IN-30

Voir tous les produits spécifiques à Isoform Indoleamine 2,3-Dioxygenase (IDO)

Voir tous les produits spécifiques à Isoform Cytochrome P450

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

IDO1-IN-30 Related Classifications

HY-178479 Related Classifications