FSC(PEG4-αvβ6)₃
FSC(PEG4-avb6)3 is a tracer targeting αvβ6 integrin trimer (IC50 = 0.69 nM). FSC(PEG4-avb6)3 can be used for the study of head-and-neck, lung, breast, and pancreatic carcinomas.
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- Fòrmula: C237H354N54O69
- Peso molecular:5063.67
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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αvβ6 0.69 nM (IC50) |
[68Ga]Ga-FSC(PEG4-avb6)3 exhibits a LogD (pH 7.4) value of -1.4, whereas [89Zr]Zr-FSC(PEG4-avb6)3 shows a LogD (pH 7.4) of -0.9[1].
[68Ga]Ga-FSC(PEG4-avb6)3 shows specific uptake of 3.9% in H2009 cells, while uptake was negligible in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Xenograft tumor-bearing models were established by subcutaneous transplantation of 5 × 106 H2009 human lung adenocarcinoma cells (αvβ6 positive) into CB17 SCID mice (female, 6-10 weeks old)[1].
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Dosage:[68Ga]Ga-FSC(PEG4-avb6)3: 120-140 pmol
[89Zr]Zr-FSC(PEG4-avb6)3: 200-400 pmol
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Administration:I.v., once
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Result:[68Ga]Ga-FSC(PEG4-avb6)3 showed tumor uptake of 1.4% ID/g.
[89Zr]Zr-FSC(PEG4-avb6)3 was suitable for extending the imaging window and showed good tumor preservation, but its stability was limited.
Chemical Information
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Peso molecular 5063.67
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Fòrmula C237H354N54O69
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SMILES
O=C(N(O)CCCC(NC(CCOCCOCCOCCOCCN1N=NC(CCCCC(NCCCC[C@H](N(C)C([C@@H]2CCCN2C([C@H](CC3=CC=C(O)C=C3)NC([C@H](C)N4)=O)=O)=O)C(N[C@@H](CC5=CC=C(O)C=C5)C(N[C@@H](CCCNC(N)=N)C(NC(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C4=O)=O)=O)=O)=O)=O)=O)=C1)=O)C(OCC/C(C)=C\C6=O)=O)/C=C(C)\CCOC(C(NC(CCOCCOCCOCCOCCN7C=C(CCCCC(NCCCC[C@H](N(C)C([C@H]8N(C([C@H](CC9=CC=C(O)C=C9)NC([C@H](C)N%10)=O)=O)CCC8)=O)C(N[C@@H](CC%11=CC=C(O)C=C%11)C(N[C@@H](CCCNC(N)=N)C(NC(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C%10=O)=O)=O)=O)=O)=O)=O)N=N7)=O)CCCN(O)C(/C=C(CCOC(C(NC(CCOCCOCCOCCOCCN%12C=C(CCCCC(NCCCC[C@H](N(C)C([C@@H]%13CCCN%13C([C@H](CC%14=CC=C(O)C=C%14)NC([C@H](C)N%15)=O)=O)=O)C(N[C@@H](CC%16=CC=C(O)C=C%16)C(N[C@@H](CCCNC(N)=N)C(NC(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C%15=O)=O)=O)=O)=O)=O)=O)N=N%12)=O)CCCN6O)=O)/C)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FSC(PEG4-αvβ6)₃ Related Classifications
HY-179583 Related Classifications
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