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Referencia número: HY-123411

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MGS0039

(Synonyms: BCI 632)

MGS0039 is a type II group mGluR antagonist. MGS0039 has a high affinity for mGluR2 and mGluR3, with K_i values of 2.2 nM and 4.5 nM, respectively. MGS0039 can attenuate the inhibitory effect of glutamate-induced cyclic AMP formation triggered by Forskolin (HY-15371) in CHO cells expressing mGluR2/mGluR3. MGS0039 shows antidepressant-like activity in rats.

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No. CAS: 569686-87-9
Fòrmula: C₁₅H₁₄Cl₂FNO₅
Peso molecular:378.18

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

MGS0039 Chemical Structure

No. CAS: 569686-87-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas mGluR :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	>100000 nM Compound: (-)-11be	Effective concentration for agonistic activity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells Effective concentration for agonistic activity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells	[PMID: 15317467]
CHO	EC₅₀	>100000 nM Compound: (-)-11be	Effective concentration for agonistic activity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells Effective concentration for agonistic activity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells	[PMID: 15317467]
CHO	EC₅₀	>100000 nM Compound: (-)-11be	Effective concentration for agonistic activity towards metabotropic glutamate receptor 5 of rat expressed in CHO cells Effective concentration for agonistic activity towards metabotropic glutamate receptor 5 of rat expressed in CHO cells	[PMID: 15317467]
CHO	EC₅₀	>100000 nM Compound: (-)-11be	Effective concentration for agonistic activity towards metabotropic glutamate receptor 6 of rat expressed in CHO cells Effective concentration for agonistic activity towards metabotropic glutamate receptor 6 of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	11700 nM Compound: (-)-11be	Concentration required to inhibit metabotropic glutamate receptor 5 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 5 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	1740 nM Compound: (-)-11be	Concentration required to inhibit metabotropic glutamate receptor 4 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 4 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	20 nM Compound: (-)-11be	Concentration required to inhibit metabotropic glutamate receptor 2 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 2 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	2060 nM Compound: (-)-11be	Concentration required to inhibit metabotropic glutamate receptor 6 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 6 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	24 nM Compound: (-)-11be	Concentration required to inhibit metabotropic glutamate receptor 3 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 3 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	93300 nM Compound: (-)-11be	Concentration required to inhibit metabotropic glutamate receptor 1 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 1 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	EC₅₀	>100000 nM Compound: (-)-11be	Effective concentration for agonistic activity towards metabotropic glutamate receptor 1 of rat expressed in CHO cells Effective concentration for agonistic activity towards metabotropic glutamate receptor 1 of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	20 nM Compound: MGS0039	Antagonist activity at mGLUR2 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP production Antagonist activity at mGLUR2 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP production	[PMID: 22318160]
CHO	IC₅₀	24 nM Compound: MGS0039	Antagonist activity at mGLUR3 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP production Antagonist activity at mGLUR3 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP production	[PMID: 22318160]

Chemical Information

No. CAS 569686-87-9
Peso molecular 378.18
Fòrmula C₁₅H₁₄Cl₂FNO₅
SMILES

O=C(O)[C@]1([C@@]2([C@](F)([C@@]2(C[C@H]1OCC3=CC=C(C(Cl)=C3)Cl)[H])C(O)=O)[H])N
Synonyms

BCI 632
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Chaki S, et al. MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity. Neuropharmacology. 2004 Mar;46(4):457-67. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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MGS0039

Ver todos los productos específicos de isoformas mGluR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

MGS0039 Related Classifications

HY-123411 Related Classifications