569686-87-9
Chemical Structure
MGS0039
Synonym(s): BCI 632
- CAS No.: 569686-87-9
- Formula:C15H14Cl2FNO5
- Molecular Weight:378.18
IUPAC Name: (1R,2R,3R,5R,6R)-2-amino-3-((3,4-dichlorobenzyl)oxy)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
InChIKey: LFAGGDAZZKUVKO-JAGWWQSPSA-N
SMILES: O=C(O)[C@]1([C@@]2([C@](F)([C@@]2(C[C@H]1OCC3=CC=C(C(Cl)=C3)Cl)[H])C(O)=O)[H])N
Biological Activity:
MGS0039 is a type II group mGluR antagonist. MGS0039 has a high affinity for mGluR2 and mGluR3, with Ki values of 2.2 nM and 4.5 nM, respectively. MGS0039 can attenuate the inhibitory effect of glutamate-induced cyclic AMP formation triggered by Forskolin (HY-15371) in CHO cells expressing mGluR2/mGluR3. MGS0039 shows antidepressant-like activity in rats[1].
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MGS0039 | MGS0039 is a type II group mGluR antagonist. MGS0039 has a high affinity for mGluR2 and mGluR3, with Ki values of 2.2 nM and 4.5 nM, respectively. MGS0039 can attenuate the inhibitory effect of glutamate-induced cyclic AMP formation triggered by Forskolin (HY-15371) in CHO cells expressing mGluR2/mGluR3. MGS0039 shows antidepressant-like activity in rats. |
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