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Referencia número: HY-117593

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NSC 23925B

NSC 23925B is a P-glycoprotein (P-gp) inhibitor, as well as the most biologically active isomer of NSC23925 (HY-19626), which reverses and prevents P-glycoprotein-mediated multidrug resistance in cancer cells. NSC 23925B shows weak inhibition against most CYP450 enzymes (IC₅₀ > 10 μM), and exhibits moderate inhibitory activity against CYP2B6 and CYP2D6 with IC₅₀ values of 8.589 μM and 1.407 μM, respectively. NSC 23925B can be used for the research of multidrug-resistant cancers.

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No. CAS: 1369591-04-7
Fòrmula: C₂₂H₂₆Cl₂N₂O₂
Peso molecular:421.36

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Please store the product under the recommended conditions in the Certificate of Analysis.

NSC 23925B Chemical Structure

No. CAS: 1369591-04-7

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In Vitro

NSC 23925B potently reverses Pgp-mediated multidrug resistance (MDR) in multidrug-resistant human breast cancer and colon cancer cell lines^[1].
NSC 23925B inhibits Pgp-mediated chemoresistance in ovarian cancer cells and osteosarcoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NSC 23925B (2.50-93.75 mg/kg; i.p.; i.v.; single dose) exhibits favorable pharmacokinetic profiles with high bioavailability, measurable plasma concentrations over 24 hours, and limited toxicity in male BALB/c mice, with a maximum tolerated dose of at least 68.80 mg/kg (i.p.) in males and 24.70 mg/kg (i.v.) in both sexes^[1].
NSC 23925B (2.50-47.20 mg/kg; i.p.; i.v.; single dose) exhibits favorable pharmacokinetic profiles with high bioavailability, measurable plasma concentrations over 24 hours, and limited toxicity in male Sprague-Dawley rats, with a maximum tolerated dose of at least 33.10 mg/kg (i.p.) and 38.80 mg/kg (i.v.) in males^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1369591-04-7
Peso molecular 421.36
Fòrmula C₂₂H₂₆Cl₂N₂O₂
SMILES

O[C@H]([C@@]1([H])CCCCN1)C2=CC(C3=CC=C(C=C3)OC)=NC4=C2C=CC=C4.Cl.Cl
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

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Instrucciones de manejo (2659 KB)

Referencias

[1]. Gao Y, et al. Pharmacokinetics and tolerability of NSC23925b, a novel P-glycoprotein inhibitor: preclinical study in mice and rats. Sci Rep. 2016 May 9;6:25659.
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NSC 23925B

Ver todos los productos específicos de isoformas Cytochrome P450

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HY-117593 Related Classifications