ORG 30276
ORG 30276 (APTAA-LHRH) is a potent GnRH antagonist that effectively reduces serum LH and FSH levels in male rats. ORG 30276 significantly decreases unoccupied pituitary GnRH receptors, leading to suppressed gonadotropin secretion. ORG 30276 treatment results in a considerable reduction in mRNA levels of gonadotropin beta-subunits in the pituitary gland. ORG 30276's effects on gonadotropin dynamics can be selectively reversed by the replacement of specific sex steroids, with androgens being particularly effective for the FSH beta-subunit mRNA levels.
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- No. CAS: 83539-08-6
- Fòrmula: C69H91Cl2N17O14
- Peso molecular:1453.47
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Actividad biológica
Chemical Information
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No. CAS 83539-08-6
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Peso molecular 1453.47
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Fòrmula C69H91Cl2N17O14
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Synonyms
APTAA-LHRH
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Sequence
Ac-{d-Phe(4-Cl)}-{d-Phe(4-Cl)}-{d-Trp}-Ser-Tyr-{d-Arg}-Leu-Arg-Pro-{d-Ala}
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Sequence Shortening
Ac-{d-Phe(4-Cl)}-{d-Phe(4-Cl)}-{d-Trp}SY-{d-Arg}-LRP-{d-Ala}
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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