HIPK3 - homeodomain interacting protein kinase 3 Gene

Also Known as PKY; YAK1; DYRK6; FIST3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10114

About HIPK3

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:33,256,672-33,357,023 (from NCBI)

This gene has 6 transcripts (splice variants), 273 orthologues and 12 paralogues. Ubiquitous expression in fat (RPKM 29.7), gall bladder (RPKM 21.4) and 25 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in mRNA transcription; negative regulation of apoptotic process; and protein phosphorylation. Located in cytosol; nuclear body; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

HIPK3 Products (4)

mRNA Protein Name
NM_001048200.3 NP_001041665.1 homeodomain-interacting protein kinase 3 isoform 2
NM_001278162.2 NP_001265091.1 homeodomain-interacting protein kinase 3 isoform 2
NM_001278163.2 NP_001265092.1 homeodomain-interacting protein kinase 3 isoform 2
NM_005734.5 NP_005725.3 homeodomain-interacting protein kinase 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein kinase activity IDA
IDA: Inferred from direct assay
14766760 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10919273 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA transcription IDA
IDA: Inferred from direct assay
17210646 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
14766760 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
14766760 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIPK3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (197 - 525)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1215 a.a.
Protein Preferred Names Protein Names

homeodomain-interacting protein kinase 3

  • ANPK

Related Diseases

Diseases Alias
Huntington Disease

  • Huntington'S Disease

  • Huntington Chorea

  • Huntington'S Chorea

  • HD

  • Huntington Chronic Progressive Hereditary Chorea

  • Juvenile Huntington Disease

  • Chronic Progressive Chorea

  • Chronic Progressive Hereditary Chorea

  • Hc - [Huntington Chorea]

  • Hereditary Chorea

  • Progressive Hereditary Chorea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123853 CAM4066 Inhibitor / Unkown
HY-177416 MU1787 Inhibitor 99.84% Unkown
HY-RS06183 HIPK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19440 Hipk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25932 Hipk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HIPK3 VGNC VGNC:41695
Mus musculus HIPK3 MGD MGI:1314882
Felis catus HIPK3 VGNC VGNC:67574
Bos taurus HIPK3 VGNC VGNC:29860
Macaca mulatta HIPK3 VGNC VGNC:73472
Rattus norvegicus HIPK3 RGD RGD:619884
Others HIPK3 NCBI