CEBPD - CCAAT enhancer binding protein delta Gene

Also Known as CELF; CRP3; C/EBP-delta; NF-IL6-beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1052

About CEBPD

Cytogenetic location: 8q11.21 Genomic coordinates (GRCh38): 8:47,736,913-47,738,164 (from NCBI)

This gene has 1 transcript (splice variant), 158 orthologues and 4 paralogues.

Summary

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]

CEBPD Products (1)

mRNA Protein Name
NM_005195.4 NP_005186.2 CCAAT/enhancer-binding protein delta

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20102225 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription regulator complex IPI
IPI: Inferred from physical interaction
20102225 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEBPD Protein Structure

bZIP_2

bZIP_2: Basic region leucine zipper (191 - 242)

  • 0
  • 100
  • 200
  • 269 a.a.
Protein Preferred Names Protein Names

CCAAT/enhancer-binding protein delta

  • CCAAT/enhancer binding protein (C/EBP), delta

CEBPD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CEBPD P49716 CEBPA Homo sapiens P49715
Peptide Array
20102225
Intra
CEBPD P49716 FANCD2 Homo sapiens Q9BXW9
Anti Tag CoIP
20805509
Intra
CEBPD P49716 FANCD2 Homo sapiens Q9BXW9
Anti Bait CoIP
20805509
Intra
CEBPD P49716 IPO4 Homo sapiens Q8TEX9
Anti Tag CoIP
20805509
Intra
CEBPD P49716 IPO4 Homo sapiens Q8TEX9
Anti Bait CoIP
20805509
Intra
CEBPD P49716 CEBPG Homo sapiens P53567
Peptide Array
20102225
Intra
CEBPD P49716 DDIT3 Homo sapiens P35638
Peptide Array
20102225
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CEBPD Proteins

Cat. No. Product Name Accession Purity
HY-P72134 CEBP delta/CEBPD Protein, Human (His-Myc) P49716 (S2-R269) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Speech And Communication Disorders

  • Language Disorder

  • Communication Disorder

  • Language Disorders

  • Communication Disorders

  • Speech Language Disorder

  • Speech-Language Disorder

  • Communication Impairment

  • Speech And Language Disorder
Developmental Coordination Disorder

  • Motor Skills Disorders
Expressive Language Disorder

  • Developmental Expressive Language Disorder
Specific Language Impairment

  • Language Impairment, Specific
Mixed Receptive-Expressive Language Disorder
Myotonic Disease

  • Myotonic Disorders

  • Myotonic Syndrome

  • Symptomatic Myotonia
Reading Disorder

  • Specific Reading Disorder

  • Reading

  • Dyslexia

  • Developmental Reading Disorder
Dysgraphia

  • Agraphia
Learning Disability

  • Learning Disabilities

  • Learning Disorders

  • Academic Skill Disorder

  • Learning Disorder
Articulation Disorder

  • Phonological Disorder

  • Articulation Disorders

  • Articulation Impairment

  • Speech Sound Disorders
Speech Disorder

  • Speech Disorders
Myotonic Dystrophy 1

  • Myotonic Dystrophy

  • Dystrophia Myotonica

  • Steinert Disease

  • Myotonic Dystrophy Type 1

  • Myotonia Atrophica

  • DM1

  • Congenital Myotonic Dystrophy

  • Myotonia Dystrophica

  • Steinert Myotonic Dystrophy

  • Dystrophia Myotonica 1

  • Dm

  • Steinert'S Disease

  • Steinert Myotonic Dystrophy Syndrome

  • Myotonic Dystrophy Of Steinert

  • Dystrophia Myotonica Type 1

  • Myotonic Dystrophy Congenital

  • Dystrophy, Myotonic, Type 1

  • Dm - [Dystrophia Myotonica]

  • Myotonic Muscular Dystrophy
Echolalia
Spinocerebellar Ataxia 8

  • Spinocerebellar Ataxia Type 8

  • SCA8

  • Ataxia, Spinocerebellar, Type 8
Dyslexia
Stuttering

  • Stammering

  • Familial Persistent Stuttering

  • Stuttering, Familial Persistent 1
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Benign Epilepsy With Centrotemporal Spikes

  • Rolandic Epilepsy

  • Benign Rolandic Epilepsy

  • Epilepsy, Rolandic

  • Bcects

  • Benign Childhood Epilepsy With Centrotemporal Spike

  • Sylvan Seizures

  • Becrs

  • Bects

  • Bre

  • Benign Epilepsy Of Childhood With Centrotemporal Spikes

  • Benign Familial Epilepsy Of Childhood With Rolandic Spikes

  • Centrotemporal Epilepsy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18991 Cebpd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02447 CEBPD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25480 Cebpd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CEBPD VGNC VGNC:106685
Rattus norvegicus CEBPD RGD RGD:2328
Mus musculus CEBPD MGD MGI:103573
Macaca mulatta CEBPD VGNC VGNC:83988
Others CEBPD NCBI