XPOT - exportin for tRNA Gene

Also Known as XPO3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11260

About XPOT

Cytogenetic location: 12q14.2 Genomic coordinates (GRCh38): 12:64,404,392-64,451,125 (from NCBI)

This gene has 6 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in thyroid (RPKM 36.4), brain (RPKM 13.8) and 25 other tissues.

Summary

This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]

XPOT Products (1)

mRNA	Protein	Name
NM_007235.6	NP_009166.2	exportin-T

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables tRNA binding	IDA IDA: Inferred from direct assay	9660920	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in tRNA export from nucleus	IDA IDA: Inferred from direct assay	9660920	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9660920	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	9660920	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	9660920	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XPOT Protein Structure

Xpo1

0
200
400
600
800
962 a.a.

Protein Preferred Names	Protein Names
exportin-T	exportin(tRNA)

XPOT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	XPOT	O43592	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	XPOT	O43592	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	XPOT	O43592	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	XPOT	O43592	TRA2A	Homo sapiens	Q13595	Y2H Prey Pooling	32296183
Intra	XPOT	O43592	TRA2A	Homo sapiens	Q13595	Validated Y2H	32296183
Intra	XPOT	O43592	TRA2A	Homo sapiens	Q13595	Y2H Array	32296183
Intra	XPOT	O43592	RAN	Homo sapiens	P62826	Y2H Array	32296183
Intra	XPOT	O43592	RAN	Homo sapiens	P62826	Validated Y2H	32296183
Intra	XPOT	O43592	RAN	Homo sapiens	P62826	Y2H Prey Pooling	32296183
Intra	XPOT	O43592	KRT75	Homo sapiens	O95678	Y2H Prey Pooling	32296183
Intra	XPOT	O43592	KRT75	Homo sapiens	O95678	Validated Y2H	32296183
Intra	XPOT	O43592	KRT75	Homo sapiens	O95678	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Severe Congenital Neutropenia 6	Autosomal Recessive Severe Congenital Neutropenia Due To Jagn1 Deficiency Scn6
Glaucoma, Normal Tension	Low Tension Glaucoma Glaucoma, Normal Tension, Susceptibility To Normal Tension Glaucoma Ntg Glaucoma, Normal Pressure NPG Glaucoma, Normal Pressure, Susceptibility To Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15894	XPOT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	XPOT	VGNC	VGNC:67116
Rattus norvegicus	XPOT	RGD	RGD:1305562
Canis familiaris	XPOT	VGNC	VGNC:48465
Mus musculus	XPOT	MGD	MGI:1920442
Macaca mulatta	XPOT	VGNC	VGNC:100123
Bos taurus	XPOT	VGNC	VGNC:37002
Others	XPOT	NCBI