Ltc4s - leukotriene C4 synthase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114097

Summary

Enables glutathione binding activity and leukotriene-C4 synthase activity. Involved in several processes, including cellular response to lipid; leukotriene biosynthetic process; and response to axon injury. Located in intracellular membrane-bounded organelle. Biomarker of glomerulonephritis and peripheral nervous system disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LTC4S (leukotriene C4 synthase). [provided by Alliance of Genome Resources, Apr 2022]

Ltc4s Products (1)

mRNA Protein Name
NM_053639.2 NP_446091.2 leukotriene C4 synthase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables glutathione binding IDA
IDA: Inferred from direct assay
18440824 RGD
enables leukotriene-C4 synthase activity IDA
IDA: Inferred from direct assay
12767051 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15084748 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
9794912 RGD
involved in cellular response to vitamin A IEP
IEP: Inferred from expression pattern
12767051 RGD
involved in leukotriene biosynthetic process IDA
IDA: Inferred from direct assay
14637132 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
19908283 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
15619010 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
12767051 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leukotriene C4 synthase

  • LTC4 synthase

  • glutathione S-transferase LTC4

  • leukotriene-C(4) synthase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-126329 AZD9898 Inhibitor 98.01% Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117143 TK05 Inhibitor 97.05% Unkown
HY-168498 GJG057 Inhibitor 98.82% Unkown
HY-RS07882 LTC4S Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21637 Ltc4s Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28155 Ltc4s Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ltc4s NCBI NCBI:4056