LTC4S - leukotriene C4 synthase Gene

Homo sapiens

Gene ID: 4056 | Gene type: protein coding

About LTC4S

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:179,793,986-179,796,647 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 182 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in fat (RPKM 3.3), lung (RPKM 2.5) and 23 other tissues.

Summary

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an Enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]

LTC4S Products(1)

mRNA	Protein	Name
NM_145867.2	NP_665874.1	leukotriene C4 synthase

LTC4S Protein Structure

MAPEG

0
100
150 a.a.

Protein Preferred Names

Protein Names

leukotriene C4 synthase

LTC4 synthase

Recombinant LTC4S Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75919	LTC4S Protein, Human (sf9, His)	Q16873 (M1-A150)	≥95%

Related Diseases

Diseases

Alias

Leukotriene C4 Synthase Deficiency

Ltc4 Synthase Deficiency

Hypotonia-Failure To Thrive-Microcephaly Syndrome

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Aspirin-Induced Respiratory Disease

Aspirin-Sensitive Asthma

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Angioedema

Angioneurotic Oedema	Quincke'S Edema
Angioneurotic Edema	Giant Urticaria

Asthma, Nasal Polyps, And Aspirin Intolerance

Asthma And Nasal Polyps	Asa Triad
Asthma, Aspirin-Induced, Susceptibility To	Asthma, Aspirin-Induced
Asthma, With Nasal Polyps And Aspirin Intolerance	ANPAI
Aia	Aspirin-Intolerant Asthma
Asthma Aspirin-Induced	Nasal Polyps Asthma And Aspirin Sensitivity
Samter Triad	Asthma With Aspirin Triad Including Nonsteroidal Anti-Inflammatory Activity And Nasal Polyps

Exercise-Induced Bronchoconstriction

Exercise-Induced Asthma

Asthma Exercise-Induced

Chronic Frontal Sinusitis

Aspirin Allergy

Acetylsalicylic Acid Allergy

Asa Allergy

Intrinsic Asthma

Non-Atopic Asthma

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-126329	AZD9898	Inhibitor	98.62%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117143	TK05	Inhibitor	98.00%	Unkown
HY-RS07882	LTC4S Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LTC4S	VGNC	VGNC:82180
Canis familiaris	LTC4S	VGNC	VGNC:51742
Bos taurus	LTC4S	VGNC	VGNC:31076
Felis catus	LTC4S	VGNC	VGNC:68106
Mus musculus	LTC4S	MGD	MGI:107498
Rattus norvegicus	LTC4S	RGD	RGD:620677
Others	LTC4S	NCBI

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