LTC4S - leukotriene C4 synthase Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4056

About LTC4S

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:179,793,986-179,796,647 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 182 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in fat (RPKM 3.3), lung (RPKM 2.5) and 23 other tissues.

Summary

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]

LTC4S Products (1)

mRNA Protein Name
NM_145867.2 NP_665874.1 leukotriene C4 synthase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
15530365 GOA
enables leukotriene-C4 synthase activity IDA
IDA: Inferred from direct assay
8706658 GOA
enables lipid binding IDA
IDA: Inferred from direct assay
8706658 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19233132 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within leukotriene metabolic process IDA
IDA: Inferred from direct assay
8706658 GOA
involved in leukotriene metabolic process IDA
IDA: Inferred from direct assay
9153254 GOA
involved in long-chain fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
27791009 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
19233132 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
12023288 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
7599836 GOA
located in nuclear membrane IDA
IDA: Inferred from direct assay
12023288 GOA
located in nuclear outer membrane IDA
IDA: Inferred from direct assay
12023288 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LTC4S Protein Structure

MAPEG

MAPEG: MAPEG family (9 - 122)

  • 0
  • 100
  • 150 a.a.
Protein Preferred Names Protein Names

leukotriene C4 synthase

  • LTC4 synthase

LTC4S Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LTC4S Q16873 FXYD3 Homo sapiens Q14802-3
Y2H Array
32296183
Intra
LTC4S Q16873 FXYD3 Homo sapiens Q14802-3
Y2H Prey Pooling
32296183
Intra
LTC4S Q16873 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
LTC4S Q16873 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
LTC4S Q16873 LTC4S Homo sapiens Q16873
X-Ray Diffraction
17632546
Intra
LTC4S Q16873 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
LTC4S Q16873 LTC4S Homo sapiens Q16873
GMS
17632548
Intra
LTC4S Q16873 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
LTC4S Q16873 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
LTC4S Q16873 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
LTC4S Q16873 FFAR3 Homo sapiens O14843
Y2H Prey Pooling
32296183
Intra
LTC4S Q16873 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
LTC4S Q16873 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
LTC4S Q16873 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
LTC4S Q16873 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
LTC4S Q16873 FFAR3 Homo sapiens O14843
Y2H Array
32296183
Intra
LTC4S Q16873 LTC4S Homo sapiens Q16873
X-Ray Diffraction
17632548
Intra
LTC4S Q16873 LTC4S Homo sapiens Q16873
EM
15530365
Intra
LTC4S Q16873 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
LTC4S Q16873 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
LTC4S Q16873 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
LTC4S Q16873 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
LTC4S Q16873 TMEM52B Homo sapiens Q4KMG9
Validated Y2H
32296183
Intra
LTC4S Q16873 SLC7A14 Homo sapiens Q8TBB6
Validated Y2H
32296183
Intra
LTC4S Q16873 SLC7A14 Homo sapiens Q8TBB6
Y2H Array
32296183
Intra
LTC4S Q16873 SLC7A14 Homo sapiens Q8TBB6
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LTC4S Proteins

Cat. No. Product Name Accession Purity
HY-P75919 LTC4S Protein, Human (sf9, His) Q16873 (M1-A150) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Leukotriene C4 Synthase Deficiency

  • Ltc4 Synthase Deficiency

  • Hypotonia-Failure To Thrive-Microcephaly Syndrome
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Aspirin-Induced Respiratory Disease

  • Aspirin-Sensitive Asthma
Urticaria

  • Nettle Rash

  • Hives

  • Wheal

  • Urticaria Nos
Angioedema

  • Angioneurotic Oedema

  • Quincke'S Edema

  • Angioneurotic Edema

  • Giant Urticaria
Asthma, Nasal Polyps, And Aspirin Intolerance

  • Asthma And Nasal Polyps

  • Asa Triad

  • Asthma, Aspirin-Induced, Susceptibility To

  • Asthma, Aspirin-Induced

  • Asthma, With Nasal Polyps And Aspirin Intolerance

  • ANPAI

  • Aia

  • Aspirin-Intolerant Asthma

  • Asthma Aspirin-Induced

  • Nasal Polyps Asthma And Aspirin Sensitivity

  • Samter Triad

  • Asthma With Aspirin Triad Including Nonsteroidal Anti-Inflammatory Activity And Nasal Polyps
Exercise-Induced Bronchoconstriction

  • Exercise-Induced Asthma

  • Asthma Exercise-Induced
Chronic Frontal Sinusitis
Aspirin Allergy

  • Acetylsalicylic Acid Allergy

  • Asa Allergy
Intrinsic Asthma

  • Non-Atopic Asthma
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-126329 AZD9898 Inhibitor 98.01% Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117143 TK05 Inhibitor 97.05% Unkown
HY-168498 GJG057 Inhibitor 98.82% Unkown
HY-RS07882 LTC4S Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21637 Ltc4s Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28155 Ltc4s Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LTC4S VGNC VGNC:82180
Canis familiaris LTC4S VGNC VGNC:51742
Bos taurus LTC4S VGNC VGNC:31076
Felis catus LTC4S VGNC VGNC:68106
Mus musculus LTC4S MGD MGI:107498
Rattus norvegicus LTC4S RGD RGD:620677
Others LTC4S NCBI