PKD1L2 - polycystin 1 like 2 (gene/pseudogene) Gene

Also Known as PC1L2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114780

About PKD1L2

Cytogenetic location: 16q23.2 Genomic coordinates (GRCh38): 16:81,100,875-81,220,394 (from NCBI)

This gene has 11 transcripts (splice variants), 309 orthologues and 10 paralogues. Biased expression in fat (RPKM 3.7), heart (RPKM 1.2) and 7 other tissues.

Summary

This gene encodes a member of the polycystin protein family. This protein may function as a G-protein-coupled component or regulator of cation channel pores. The long isoform of this protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, Lipoxygenase, alpha-toxin (PLAT) domain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene is a polymorphic pseudogene in humans. [provided by RefSeq, May 2022]

PKD1L2 Products (4)

mRNA Protein Name
NM_001076780.3 NP_001070248.2 polycystic kidney disease protein 1-like 2 isoform c precursor
NM_001278423.2 NP_001265352.1 polycystic kidney disease protein 1-like 2 isoform e
NM_001278425.3 NP_001265354.2 polycystic kidney disease protein 1-like 2 isoform d
NM_052892.5 NP_443124.4 polycystic kidney disease protein 1-like 2 isoform a precursor
Protein Preferred Names Protein Names

polycystic kidney disease protein 1-like 2

  • PC1-like 2 protein

Related Diseases

Diseases Alias
Polycystic Kidney Disease

  • Polycystic Kidney Diseases

  • Pkd

  • Polycystic Renal Disease

  • Kidney Disease, Polycystic

  • Polycystic Kidney, Autosomal Dominant
Kidney Disease

  • Renal Failure

  • Kidney Failure

  • Kidney Diseases

  • Nephropathy

  • Abnormality Of The Kidney

  • Impaired Renal Function Disease

  • Renal Anomaly

  • Kidney Dysfunction

  • Renal Disease

  • Nephropathies

  • Renal Failure Adverse Event

  • Abnormal Renal Function
Conduct Disorder
Macular Degeneration, Age-Related, 10

  • ARMD10

  • Age Related Macular Degeneration 10

  • Macular Degeneration, Age-Related, Type 10
Autosomal Dominant Polycystic Kidney Disease

  • Polycystic Kidney Disease, Adult Type

  • Adpkd

  • Polycystic Kidney Diseases

  • Polycystic Kidney, Autosomal Dominant

  • Congenital Biliary Ectasias

  • Polycystic Kidney And Hepatic Disease 1

  • Polycystic Kidney Disease, Autosomal Dominant

  • Kidney, Polycystic, Disease, Autosomal Dominant

  • Adult Polycystic Kidney Disease

  • Polycystic Kidney, Adult Type

  • Apckd - [Autosomal Polycystic Kidney Disease]
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

  • Polycystic Kidney Disease 1

  • PKD1

  • Adpkd

  • Polycystic Kidney Disease, Adult, Type I

  • Apkd1

  • Potter Type Iii Polycystic Kidney Disease

  • Polycystic Kidney Disease, Adult

  • Potter Type Iii Polycystic Kidney Disease, Formerly

  • Polycystic Kidney Disease, Type 1

  • Adpkd1

  • Adult Polycystic Kidney Disease Type 1

  • Autosomal Dominant Polycystic Kidney Disease 1

  • Pkd-1

  • Polycystic Kidney Disease Adult

  • Polycystic Kidney Disease Type I

  • Polycystic Kidneys

  • Polycystic Kidney Disease, Adult Type I

  • Polycystic Kidney Type 1 Autosomal Dominant Disease

  • Kidney Disease, Polycystic, Type 1

  • Polycystic Kidney, Autosomal Dominant

  • Polycystic Kidney, Type 1 Autosomal Dominant Disease

  • Polycystic Kidney Diseases
Cystic Kidney Disease

  • Renal Cyst

  • Simple Renal Cyst

  • Kidney Cysts

  • Kidney Diseases, Cystic

  • Renal Cysts

  • Kidney Cyst

  • Cystic Kidney

  • Congenital Cystic Kidney Disease

  • Cystic Kidney Diseases

  • Bosniak 1 Cyst
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15698 CRT0066101 99.88% Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13687 IKK 16 Inhibitor 99.88% Unkown
HY-15698A CRT0066101 dihydrochloride 99.97% Unkown
HY-13687A IKK 16 hydrochloride Inhibitor 99.95% Unkown
HY-12239 CID755673 Inhibitor 99.13% Unkown
HY-118052 BPKDi Inhibitor 99.74% Unkown
HY-15528 kb NB 142-70 Inhibitor 98.02% Unkown
HY-151374 3-IN-PP1 Inhibitor 99.37% Unkown
HY-112547 CRT5 Inhibitor 98.70% Unkown
HY-15698B CRT0066101 trihydrochloride / Unkown
HY-RS00006 PKD1L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PKD1L2 RGD RGD:1588631
Mus musculus PKD1L2 MGD MGI:2664668
Canis familiaris PKD1L2 VGNC VGNC:56013
Others PKD1L2 NCBI