LMTK3 - lemur tyrosine kinase 3 Gene

Also Known as LMR3; TYKLM3; PPP1R101

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114783

About LMTK3

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,485,271-48,513,680 (from NCBI)

This gene has 7 transcripts (splice variants), 147 orthologues and 1 paralogue. Biased expression in brain (RPKM 7.4), duodenum (RPKM 0.9) and 5 other tissues.

Summary

Predicted to enable protein kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be located in Golgi membrane; axon; and dendrite. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

LMTK3 Products (2)

mRNA Protein Name
NM_001080434.2 NP_001073903.2 serine/threonine-protein kinase LMTK3 precursor
NM_001388485.1 NP_001375414.1 serine/threonine-protein kinase LMTK3 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21602804 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LMTK3 Protein Structure

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (134 - 407)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1460 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase LMTK3

  • protein phosphatase 1, regulatory subunit 101

LMTK3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LMTK3 Q96Q04 ESR1 Homo sapiens P03372
Anti Bait CoIP
21602804
Intra
LMTK3 Q96Q04 ESR1 Homo sapiens P03372
Protein Kinase Assay
21602804
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy

  • Catecholaminergic Polymorphic Ventricular Tachycardia 1

  • Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

  • CPVT1

  • Ventricular Tachycardia, Stress-Induced Polymorphic

  • Vtsip

  • Bidirectional Tachycardia

  • Stress-Induced Polymorphic Ventricular Tachycardia

  • Cvpt1

  • Double Tachycardia Induced By Catecholamines

  • Malignant Paroxysmal Ventricular Tachycardia

  • Multifocal Ventricular Premature Beats

  • Paroxysmal Ventricular Fibrillation

  • Syncopal Paroxysmal Tachycardia

  • Syncopal Tachyarythmia

  • Ventricular Tachycardia Catecholaminergic Polymorphic 1

  • Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 1

  • Multifocal Pvcs

  • Multifocal Premature Ventricular Beats

  • Paroxysmal Familial Ventricular Fibrillation

  • Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153896 LMTK3-IN-1 Inhibitor 98.74% Unkown
HY-RS07726 LMTK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus LMTK3 VGNC VGNC:30942
Mus musculus LMTK3 MGD MGI:3039582
Rattus norvegicus LMTK3 RGD RGD:1588641
Others LMTK3 NCBI