Adam15 - a disintegrin and metallopeptidase domain 15 (metargidin) Gene

Also Known as AD56; MDC15

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11490

Summary

This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is prominently expressed in vascular cells, the endocardium, hypertrophic cells in developing bone, and specific areas of hippocampus and cerebellum. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein have increased bone mass resulting from osteoblast proliferation, and exhibit reduced neovascularization in a mouse model for retinopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, May 2016]

Adam15 Products (13)

mRNA Protein Name
NM_001037722.4 NP_001032811.2 disintegrin and metalloproteinase domain-containing protein 15 isoform a preproprotein
NM_001409479.1 NP_001396408.1 disintegrin and metalloproteinase domain-containing protein 15 isoform c preproprotein
NM_001409480.1 NP_001396409.1 disintegrin and metalloproteinase domain-containing protein 15 isoform d preproprotein
NM_001409481.1 NP_001396410.1 disintegrin and metalloproteinase domain-containing protein 15 isoform e preproprotein
NM_001409482.1 NP_001396411.1 disintegrin and metalloproteinase domain-containing protein 15 isoform f precursor
NM_001409483.1 NP_001396412.1 disintegrin and metalloproteinase domain-containing protein 15 isoform g precursor
NM_001409484.1 NP_001396413.1 disintegrin and metalloproteinase domain-containing protein 15 isoform h precursor
NM_001409485.1 NP_001396414.1 disintegrin and metalloproteinase domain-containing protein 15 isoform i
NM_001409486.1 NP_001396415.1 disintegrin and metalloproteinase domain-containing protein 15 isoform j precursor
NM_001409487.1 NP_001396416.1 disintegrin and metalloproteinase domain-containing protein 15 isoform k precursor
NM_001409488.1 NP_001396417.1 disintegrin and metalloproteinase domain-containing protein 15 isoform m
NM_001409489.1 NP_001396418.1 disintegrin and metalloproteinase domain-containing protein 15 isoform l
NM_009614.4 NP_033744.1 disintegrin and metalloproteinase domain-containing protein 15 isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10531379 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cardiac epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
19156209 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 15

  • a disintegrin and metalloprotease domain 15 (metargidin)

  • metalloprotease RGD disintegrin protein

  • metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15

Recombinant Adam15 Proteins

Cat. No. Product Name Accession Purity
HY-P75564 ADAM15 Protein, Mouse (HEK293, His) O88839 (R18-T697) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0863 Methyl protodioscin 99.67% Unkown
HY-RS00270 ADAM15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18692 Adam15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25179 Adam15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adam15 NCBI NCBI:8751