ADAM15 - ADAM metallopeptidase domain 15 Gene

Homo sapiens

Also known as MDC15

Gene ID: 8751 | Gene type: protein coding

About ADAM15

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:155,051,316-155,062,775 (from NCBI)

This gene has 32 transcripts (splice variants), 192 orthologues and 20 paralogues. Ubiquitous expression in skin (RPKM 41.3), esophagus (RPKM 32.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the Integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

ADAM15 Products(9)

mRNA	Protein	Name
NM_001261464.2	NP_001248393.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 7 preproprotein
NM_001261465.2	NP_001248394.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 8 preproprotein
NM_001261466.2	NP_001248395.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 9 preproprotein
NM_003815.5	NP_003806.3	disintegrin and metalloproteinase domain-containing protein 15 isoform 2 preproprotein
NM_207191.3	NP_997074.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 1 preproprotein
NM_207194.3	NP_997077.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 3 preproprotein
NM_207195.3	NP_997078.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 4 preproprotein
NM_207196.3	NP_997079.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 5 preproprotein
NM_207197.3	NP_997080.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 6 preproprotein

ADAM15 Protein Structure

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
800
863 a.a.

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 15

MDC-15

Recombinant ADAM15 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75533	ADAM15 Protein, Human (HEK293, His)	Q13444 (D207-T696)	≥95%
HY-P75534	ADAM15 Protein, Human (CHO, His)	Q13444 (D207-T696)	≥95%

Related Diseases

Diseases

Alias

Sorsby Fundus Dystrophy

SFD	Fundus Dystrophy, Pseudoinflammatory, Of Sorsby
Sorsby'S Fundus Dystrophy	Macular Dystrophy, Hemorrhagic
Hemorrhagic Macular Dystrophy	Pseudoinflammatory Fundus Dystrophy Of Sorsby
Sorsby'S Pseudoinflammatory Macular Dystrophy	Sorsby Pseudoinflammatory Fundus Dystrophy
Dystrophy, Fundus, Sorsby

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00270	ADAM15 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ADAM15	VGNC	VGNC:37575
Macaca mulatta	ADAM15	VGNC	VGNC:69477
Felis catus	ADAM15	VGNC	VGNC:59576
Bos taurus	ADAM15	VGNC	VGNC:25606
Rattus norvegicus	ADAM15	RGD	RGD:620402
Mus musculus	ADAM15	MGD	MGI:1333882
Others	ADAM15	NCBI

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