Cyp19a1 - cytochrome P450, family 19, subfamily a, polypeptide 1 Gene

Also Known as Ar; ArKO; Int5; Cyp19; Int-5; p450arom

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13075

About Cyp19a1

Chromosome 9: 54,073,221-54,175,394 reverse strand.GRCm39:CM001002.3

This gene has 5 transcripts (splice variants), 319 orthologues, 20 paralogues and is associated with 163 phenotypes. Biased expression in ovary adult (RPKM 2.4) and testis adult (RPKM 1.).

Summary

Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including negative regulation of macrophage chemotaxis; reproductive structure development; and testosterone biosynthetic process. Predicted to be located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Predicted to be active in endoplasmic reticulum. Is expressed in central nervous system; early conceptus; gonad; retina; and stomach. Used to study Sjogren's syndrome and aromatase excess syndrome. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (Cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp19a1 Products (4)

mRNA Protein Name
NM_007810.4 NP_031836.1 aromatase
NM_001348172.1 NP_001335101.1 aromatase
NM_001348171.1 NP_001335100.1 aromatase
NM_001348173.1 NP_001335102.1 aromatase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
IDA: Inferred from direct assay
7669221 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within androgen metabolic process IMP
IMP: Inferred from mutant phenotype
11356695 MGI
acts upstream of or within female genitalia development IMP
IMP: Inferred from mutant phenotype
9618522 MGI
acts upstream of or within female gonad development IMP
IMP: Inferred from mutant phenotype
9618522 MGI
acts upstream of or within mammary gland development IMP
IMP: Inferred from mutant phenotype
9618522 MGI
acts upstream of or within negative regulation of chronic inflammatory response IMP
IMP: Inferred from mutant phenotype
25447050 MGI
acts upstream of or within negative regulation of macrophage chemotaxis IMP
IMP: Inferred from mutant phenotype
25447050 MGI
acts upstream of or within prostate gland growth IMP
IMP: Inferred from mutant phenotype
11356695 MGI
acts upstream of or within testosterone biosynthetic process IMP
IMP: Inferred from mutant phenotype
9618522 MGI
acts upstream of or within uterus development IMP
IMP: Inferred from mutant phenotype
9618522 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cyp19a1 Protein Structure

CYP19A1

CYP19A1: cd20616 (71 - 484)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 503 a.a.
Protein Preferred Names Protein Names

aromatase

  • CYPXIX

  • cytochrome P-450AROM

  • cytochrome P450 19A1

  • cytochrome P450, 19, aromatase

  • estrogen synthase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-113986 Dexfadrostat Inhibitor 98.75% Phase 2

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-133668 Monoethyl phthalate Activator 98.58% Unkown
HY-150775 CYP19A1-IN-2 Inhibitor 99.31% Unkown
HY-133668S Monoethyl phthalate-d4 Activator 98.36% Unkown
HY-155493 CYP19A1/CYP11B2-IN-1 Inhibitor 99.85% Unkown
HY-N9551 Eriodictyol chalcone Inhibitor 97.25% Unkown
HY-113986C Dexfadrostat hydrochloride Inhibitor / Unkown
HY-122744 CYP11B1-IN-1 Inhibitor / Unkown
HY-173279 CYP19A1-IN-1 Inhibitor / Unkown
HY-181163 Caspase-3/7 activator 4 / Unkown
HY-RS03438 CYP19A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03439 Cyp19a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03440 CYP19A1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-Z4488 5-Dibromomethyl anastrozole Control / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp19a1 NCBI NCBI:1588