NUDT16 - nudix hydrolase 16 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 131870

About NUDT16

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:131,381,671-131,388,830 (from NCBI)

This gene has 3 transcripts (splice variants), 183 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 14.5), kidney (RPKM 13.4) and 25 other tissues.

Summary

Enables several functions, including RNA binding activity; metal ion binding activity; and purine ribonucleoside triphosphate binding activity. Involved in IDP catabolic process; RNA metabolic process; and positive regulation of cell cycle process. Located in cytoplasm; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NUDT16 Products (3)

mRNA Protein Name
NM_001171905.2 NP_001165376.1 U8 snoRNA-decapping enzyme isoform 3
NM_001171906.2 NP_001165377.1 U8 snoRNA-decapping enzyme isoform 1
NM_152395.3 NP_689608.2 U8 snoRNA-decapping enzyme isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IDA
IDA: Inferred from direct assay
15053875 GOA
enables IDP phosphatase activity IDA
IDA: Inferred from direct assay
20385596 GOA
enables chloride ion binding IDA
IDA: Inferred from direct assay
29483298 GOA
enables cobalt ion binding IDA
IDA: Inferred from direct assay
17567574 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
26121039 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
21337011 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
17567574 GOA
enables manganese ion binding IDA
IDA: Inferred from direct assay
17567574 GOA
enables metalloexopeptidase activity IDA
IDA: Inferred from direct assay
21337011 GOA
enables phosphodiesterase decapping endonuclease activity IDA
IDA: Inferred from direct assay
29483298 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
17567574 GOA
enables snoRNA binding IDA
IDA: Inferred from direct assay
18820299 GOA
Biological Process GO Annotation Evidence References Source
involved in NAD-cap decapping IDA
IDA: Inferred from direct assay
32432673 GOA
involved in mRNA catabolic process IDA
IDA: Inferred from direct assay
21070968 GOA
involved in positive regulation of cell cycle process IMP
IMP: Inferred from mutant phenotype
20385596 GOA
involved in sno(s)RNA catabolic process IDA
IDA: Inferred from direct assay
15053875 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20385596 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
20385596 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20385596 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDT16 Protein Structure

NUDIX

NUDIX: NUDIX domain (45 - 119)

  • 0
  • 100
  • 195 a.a.
Protein Preferred Names Protein Names

U8 snoRNA-decapping enzyme

  • IDP phosphatase

NUDT16 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NUDT16 Q96DE0 MTIF2 Homo sapiens P46199
Anti Tag CoIP
33961781
Intra
NUDT16 Q96DE0 NUDT16 Homo sapiens Q96DE0
X-Ray Diffraction
26121039
Intra
NUDT16 Q96DE0 ACSF2 Homo sapiens Q96CM8
Anti Tag CoIP
33961781
Intra
NUDT16 Q96DE0 D2HGDH Homo sapiens Q8N465
Anti Tag CoIP
33961781
Intra
NUDT16 Q96DE0 NUDT16 Homo sapiens Q96DE0
GMS
26121039
Intra
NUDT16 Q96DE0 ATP12A Homo sapiens P54707
Anti Tag CoIP
33961781
Intra
NUDT16 Q96DE0 COL20A1 Homo sapiens Q9P218
Anti Tag CoIP
33961781
Intra
NUDT16 Q96DE0 UBR2 Homo sapiens Q8IWV8
Anti Tag CoIP
33961781
Intra
NUDT16 Q96DE0 BCKDK Homo sapiens O14874
Anti Tag CoIP
33961781
Intra
NUDT16 Q96DE0 CRAT Homo sapiens P43155
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16965 TH287 Inhibitor 98.99% Unkown
HY-RS09666 NUDT16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09667 NUDT16L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-16965A TH287 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NUDT16 RGD RGD:1311387
Canis familiaris NUDT16 VGNC VGNC:44028
Mus musculus NUDT16 MGD MGI:1922936
Bos taurus NUDT16 VGNC VGNC:32330
Felis catus NUDT16 VGNC VGNC:102790
Others NUDT16 NCBI