Rxfp2 - relaxin/insulin-like family peptide receptor 2 Gene

Also Known as Lgr8; Great; Gpr106

Species: Mus musculus

Gene Type: protein coding
Gene ID: 140498

Summary

Enables protein-hormone receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway and male gonad development. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; and peritoneum. Used to study cryptorchidism. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human RXFP2 (relaxin family peptide receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Rxfp2 Products (3)

mRNA Protein Name
NM_001289564.1 NP_001276493.1 relaxin receptor 2 isoform 2 precursor
NM_001289566.1 NP_001276495.1 relaxin receptor 2 isoform 3 precursor
NM_080468.2 NP_536716.2 relaxin receptor 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein-hormone receptor activity IMP
IMP: Inferred from mutant phenotype
12217959 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12217959 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
12217959 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

relaxin receptor 2

  • G protein coupled receptor affecting testicular descent

  • G protein-coupled receptor 106

  • leucine-rich repeat-containing G protein-coupled receptor 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150186 RXFP2 agonist 2 / Unkown
HY-150185 RXFP2 agonist 1 / Unkown
HY-RS12358 RXFP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992108 Efadirelaxin alfa Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rxfp2 NCBI NCBI:122042