2. Gene
  3. Rxfp2 - relaxin/insulin-like family peptide receptor 2 Gene

Rxfp2 - relaxin/insulin-like family peptide receptor 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Lgr8; Great; Gpr106

Gene ID: 140498 | Gene type: protein coding

About Rxfp2

Summary

Enables protein-hormone receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway and male gonad development. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; and peritoneum. Used to study cryptorchidism. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human RXFP2 (relaxin family peptide receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Rxfp2 Products(3)

mRNA Protein Name
NM_001289564.1 NP_001276493.1 relaxin receptor 2 isoform 2 precursor
NM_001289566.1 NP_001276495.1 relaxin receptor 2 isoform 3 precursor
NM_080468.2 NP_536716.2 relaxin receptor 2 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein-hormone receptor activity IMP
IMP: Inferred from mutant phenotype
12217959 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12217959 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
12217959 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

relaxin receptor 2

G protein coupled receptor affecting testicular descent

G protein-coupled receptor 106

leucine-rich repeat-containing G protein-coupled receptor 8

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150186 RXFP2 agonist 2 / Unkown
HY-150185 RXFP2 agonist 1 / Unkown
HY-RS12358 RXFP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P992108 Efadirelaxin alfa Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rxfp2 NCBI NCBI:122042