DGKA - diacylglycerol kinase alpha Gene

Also Known as DAGK; DAGK1; DGK-alpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1606

About DGKA

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,931,162-55,954,023 (from NCBI)

This gene has 49 transcripts (splice variants), 263 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 36.2), skin (RPKM 31.7) and 19 other tissues.

Summary

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017]

DGKA Products (21)

mRNA Protein Name
NM_001345.5 NP_001336.2 diacylglycerol kinase alpha isoform a
NM_001351033.2 NP_001337962.1 diacylglycerol kinase alpha isoform a
NM_001351034.2 NP_001337963.1 diacylglycerol kinase alpha isoform a
NM_001351035.1 NP_001337964.1 diacylglycerol kinase alpha isoform b
NM_001351036.2 NP_001337965.1 diacylglycerol kinase alpha isoform c
NM_001351037.1 NP_001337966.1 diacylglycerol kinase alpha isoform c
NM_001351038.2 NP_001337967.1 diacylglycerol kinase alpha isoform d
NM_001351039.2 NP_001337968.1 diacylglycerol kinase alpha isoform d
NM_001351040.2 NP_001337969.1 diacylglycerol kinase alpha isoform d
NM_001413596.1 NP_001400525.1 diacylglycerol kinase alpha isoform a
NM_001413597.1 NP_001400526.1 diacylglycerol kinase alpha isoform a
NM_001413598.1 NP_001400527.1 diacylglycerol kinase alpha isoform a
NM_001413599.1 NP_001400528.1 diacylglycerol kinase alpha isoform e
NM_001413600.1 NP_001400529.1 diacylglycerol kinase alpha isoform e
NM_001413601.1 NP_001400530.1 diacylglycerol kinase alpha isoform e
NM_001413602.1 NP_001400531.1 diacylglycerol kinase alpha isoform f
NM_001413603.1 NP_001400532.1 diacylglycerol kinase alpha isoform f
NM_001413604.1 NP_001400533.1 diacylglycerol kinase alpha isoform g
NM_201444.3 NP_958852.1 diacylglycerol kinase alpha isoform a
NM_201445.2 NP_958853.1 diacylglycerol kinase alpha isoform a
NM_201554.2 NP_963848.1 diacylglycerol kinase alpha isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP-dependent diacylglycerol kinase activity IDA
IDA: Inferred from direct assay
2175712 GOA
enables kinase activity IDA
IDA: Inferred from direct assay
18004883 GOA
enables lipid binding IDA
IDA: Inferred from direct assay
22627129 GOA
Biological Process GO Annotation Evidence References Source
involved in diacylglycerol metabolic process IDA
IDA: Inferred from direct assay
2175712 GOA
involved in glycerolipid metabolic process IDA
IDA: Inferred from direct assay
22627129 GOA
involved in lipid phosphorylation IDA
IDA: Inferred from direct assay
2175712 GOA
involved in phosphatidic acid biosynthetic process IDA
IDA: Inferred from direct assay
2175712 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
2175712 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DGKA Protein Structure

DAG_kinase_N

DAG_kinase_N: Diacylglycerol kinase N-terminus (2 - 86)

DAG_kinase_N

DAG_kinase_N: Diacylglycerol kinase N-terminus (90 - 110)

EF-hand_6

EF-hand_6: EF-hand domain (115 - 139)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (206 - 253)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (270 - 321)

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (376 - 500)

DAGK_acc

DAGK_acc: Diacylglycerol kinase accessory domain (521 - 701)

  • 0
  • 200
  • 400
  • 600
  • 735 a.a.
Protein Preferred Names Protein Names

diacylglycerol kinase alpha

  • 80 kDa diacylglycerol kinase

DGKA Antibodies

Cat. No. Product Name Application Reactivity
HY-P83116 DGKA Antibody (YA2861) WB, IHC-P, IP Human
HY-P83116A DGKA Antibody (YA2861)(PBS only) WB, IHC-P, IP Human

Related Diseases

Diseases Alias
Lymphoproliferative Syndrome, X-Linked, 1

  • Lymphomatoid Papulosis

  • Duncan Disease

  • Purtilo Syndrome

  • X-Linked Lymphoproliferative Syndrome

  • Xlp

  • X-Linked Lymphoproliferative Disease

  • XLP1

  • Lyp

  • Lymphoproliferative Disease, X-Linked

  • Xlpd

  • X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency

  • Ebv Infection, Severe, Susceptibility To

  • Ebvs

  • Immunodeficiency 5

  • Imd5

  • X-Linked Lymphoproliferative Syndrome 1

  • Epstein-Barr Virus Infection, Familial Fatal

  • Ebv Infection, Severe

  • Infectious Mononucleosis, Severe

  • Infectious Mononucleosis, Severe, Susceptibility To

  • Immunodeficiency, X-Linked Progressive Combined Variable

  • Epstein Barr Virus Infection, Familial Fatal

  • X-Linked Progressive Combined Variable Immunodeficiency 5

  • Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males

  • Familial Fatal Epstein-Barr Infection

  • Severe Susceptibility To Ebv Infection

  • Severe Susceptibility To Infectious Mononucleosis

  • Sap Deficiency

  • Sh2d1a/Slam-Associated Protein Deficiency

  • X-Linked Lymphoproliferative Syndrome Type 1

  • X-Linked Progressive Combined Variable Immunodeficiency

  • Lymphoproliferative Syndrome, X-Linked

  • Sap

  • X-Linked Lymphoproliferative Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135898 DGK-IN-1 Inhibitor 98.67% Unkown
HY-117168 1,2-Dilinoleoyl-sn-glycerol 97.09% Unkown
HY-RS03715 DGKA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18236 Dgka Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24715 Dgka Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DGKA VGNC VGNC:28024
Canis familiaris DGKA VGNC VGNC:39915
Rattus norvegicus DGKA RGD RGD:70904
Felis catus DGKA VGNC VGNC:61458
Macaca mulatta DGKA VGNC VGNC:71780
Mus musculus DGKA MGD MGI:102952
Others DGKA NCBI