2. Gene
  3. DGKA - diacylglycerol kinase alpha Gene

DGKA - diacylglycerol kinase alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DAGK; DAGK1; DGK-alpha

Gene ID: 1606 | Gene type: protein coding

About DGKA

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,931,162-55,954,023 (from NCBI)

This gene has 49 transcripts (splice variants), 263 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 36.2), skin (RPKM 31.7) and 19 other tissues.

Summary

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017]

DGKA Products(21)

mRNA Protein Name
NM_001345.5 NP_001336.2 diacylglycerol kinase alpha isoform a
NM_001351033.2 NP_001337962.1 diacylglycerol kinase alpha isoform a
NM_001351034.2 NP_001337963.1 diacylglycerol kinase alpha isoform a
NM_001351035.1 NP_001337964.1 diacylglycerol kinase alpha isoform b
NM_001351036.2 NP_001337965.1 diacylglycerol kinase alpha isoform c
NM_001351037.1 NP_001337966.1 diacylglycerol kinase alpha isoform c
NM_001351038.2 NP_001337967.1 diacylglycerol kinase alpha isoform d
NM_001351039.2 NP_001337968.1 diacylglycerol kinase alpha isoform d
NM_001351040.2 NP_001337969.1 diacylglycerol kinase alpha isoform d
NM_001413596.1 NP_001400525.1 diacylglycerol kinase alpha isoform a
NM_001413597.1 NP_001400526.1 diacylglycerol kinase alpha isoform a
NM_001413598.1 NP_001400527.1 diacylglycerol kinase alpha isoform a
NM_001413599.1 NP_001400528.1 diacylglycerol kinase alpha isoform e
NM_001413600.1 NP_001400529.1 diacylglycerol kinase alpha isoform e
NM_001413601.1 NP_001400530.1 diacylglycerol kinase alpha isoform e
NM_001413602.1 NP_001400531.1 diacylglycerol kinase alpha isoform f
NM_001413603.1 NP_001400532.1 diacylglycerol kinase alpha isoform f
NM_001413604.1 NP_001400533.1 diacylglycerol kinase alpha isoform g
NM_201444.3 NP_958852.1 diacylglycerol kinase alpha isoform a
NM_201445.2 NP_958853.1 diacylglycerol kinase alpha isoform a
NM_201554.2 NP_963848.1 diacylglycerol kinase alpha isoform a

DGKA Protein Structure

DAG_kinase_N

DAG_kinase_N: Diacylglycerol kinase N-terminus (2 - 86)

DAG_kinase_N

DAG_kinase_N: Diacylglycerol kinase N-terminus (90 - 110)

EF-hand_6

EF-hand_6: EF-hand domain (115 - 139)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (206 - 253)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (270 - 321)

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (376 - 500)

DAGK_acc

DAGK_acc: Diacylglycerol kinase accessory domain (521 - 701)

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  • 735 a.a.
Protein Preferred Names Protein Names

diacylglycerol kinase alpha

80 kDa diacylglycerol kinase

Recombinant DGKA Proteins

Cat. No. Product Name Accession Purity
HY-P72173 DGKA Protein, Human (His) P23743 (M1-S735) ≥95%

Related Diseases

Diseases Alias
Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis

Duncan Disease

Purtilo Syndrome

X-Linked Lymphoproliferative Syndrome

Xlp

X-Linked Lymphoproliferative Disease

XLP1

Lyp

Lymphoproliferative Disease, X-Linked

Xlpd

X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency

Ebv Infection, Severe, Susceptibility To

Ebvs

Immunodeficiency 5

Imd5

X-Linked Lymphoproliferative Syndrome 1

Epstein-Barr Virus Infection, Familial Fatal

Ebv Infection, Severe

Infectious Mononucleosis, Severe

Infectious Mononucleosis, Severe, Susceptibility To

Immunodeficiency, X-Linked Progressive Combined Variable

Epstein Barr Virus Infection, Familial Fatal

X-Linked Progressive Combined Variable Immunodeficiency 5

Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males

Familial Fatal Epstein-Barr Infection

Severe Susceptibility To Ebv Infection

Severe Susceptibility To Infectious Mononucleosis

Sap Deficiency

Sh2d1a/Slam-Associated Protein Deficiency

X-Linked Lymphoproliferative Syndrome Type 1

X-Linked Progressive Combined Variable Immunodeficiency

Lymphoproliferative Syndrome, X-Linked

Sap

X-Linked Lymphoproliferative Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03715 DGKA Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DGKA VGNC VGNC:28024
Canis familiaris DGKA VGNC VGNC:39915
Rattus norvegicus DGKA RGD RGD:70904
Felis catus DGKA VGNC VGNC:61458
Macaca mulatta DGKA VGNC VGNC:71780
Mus musculus DGKA MGD MGI:102952
Others DGKA NCBI