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DGKA Antibody (YA2861)(PBS only)

(Synonyms: DAGK; DAGK1; DGK-alpha)

DGKA Antibody (YA2861) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DGKA.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, IP

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • DGKA Antibody (YA2861)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:500-1:1000 1:500-1:2000 1:20-1:50

Product Details

Description

DGKA Antibody (YA2861) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DGKA.

  • Host Rabbit
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 83 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 83 kDa
Immunogen

Recombinant protein of human DGKA aa511-700.

Purification

Affinity Purified

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    DGKA is a Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids (Probable). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group. Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol[1][2][3].

  • Subcellular Localization

    Cytoplasm, cytosol

  • Expression


    Tissue_specificity:Expressed in lymphocytes

  • Isoforms & Post-Translational Modification

    P23743 has 3 isomers: P23743-1: 82630 Da (predicted); P23743-2: 13486 Da (predicted); P23743-3: 28094 Da (predicted).

  • Subunit

    Monomer

  • SwissProt ID

    P23743

  • Gene ID
    1606 [NCBI]
  • Synonyms

    DAGK; DAGK1; DGK-alpha

  • Research Field

    Signal Transduction

DGKA Antibody (YA2861)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • DGKA Antibody (YA2861)(PBS only) Product Image