DGKA
DGKα belongs to the type I branch of diacylglycerol kinases, enzymes that phosphorylate diacylglycerol to phosphatidic acid, thereby both terminating DAG-dependent PKC signaling and generating the lipid second messenger PA. DGKα carries a recoverin homology domain containing a pair of calcium-binding EF-hand motifs plus two C1 domains, making its activity calcium-sensitive. It is abundant in lymphoid tissues and has been studied extensively in T cells, where it enforces anergy and limits T-cell receptor-driven signaling. Through these actions DGKα shapes adaptive immune responses and is pursued as a target for immuno-oncology and for improving engineered T-cell therapies.
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DGKA Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
