1,2-Dilinoleoyl-sn-glycerol 

1,2-Dilinoleoyl-sn-glycerol is a diacylglycerol (DAG) with linoleic acid (HY-N0729) (18:2) side chains attached at both the sn-1 and sn-2 positions. 1,2-Dilinoleoyl-sn-glycerol can be prepared from L-dilinoleoylphosphatidylcholine via hydrolysis with phospholipase C^[1][2][3].

1,2-Dilinoleoyl-sn-glycerol (10 min) is catalyzed for phosphorylation by purified Dictyostelium discoideum DGKA with peak specific activity of ~250 nmol/min/mg at pH 7.0, shows higher activity toward this dipolyunsaturated substrate than toward monounsaturated or mixed saturated/polyunsaturated long-chain diacylglycerols, and has its activity enhanced ~10-fold by phosphatidylserine^[2].
1,2-Dilinoleoyl-sn-glycerol levels in pooled human fecal samples decrease with extended storage at -20°C (to 0.27-fold after 1 month), 4°C (to 0.46-fold after 48 h), and room temperature (to 0.50-fold after 48 h) relative to -80°C storage, and its ratio with N-linoleoyl leucine serves as a useful lipidomic stability marker for fecal samples^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

616.95

C₃₉H₆₈O₅

24529-89-3

Liquid

Colorless to light yellow

OC[C@@H](COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)OC(CCCCCCC/C=C\C/C=C\CCCCC)=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Laakso P, et al. Chromatographic resolution of chiral diacylglycerol derivatives: potential in the stereospecific analysis of triacyl-sn-glycerols. Lipids. 1990;25(6):349-353.

  [2]. Ostroski M, et al. Analysis of a novel diacylglycerol kinase from Dictyostelium discoideum: DGKA. Biochemistry. 2005 Aug 2;44(30):10199-207.

  [3]. Sawada H, et al. Investigation of Storage Conditions and Quality Control Markers for Metabolites and Lipids in Human Feces. Metabolites. 2026;16(2):113. Published 2026 Feb 4.