Kcnmb1 - potassium large conductance calcium-activated channel, subfamily M, beta member 1 Gene

Also Known as BKbeta1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16533

Summary

Enables calcium-activated Potassium Channel activity. Predicted to be involved in several processes, including cellular response to bile acid; cellular response to ethanol; and detection of calcium ion. Predicted to act upstream of or within ion transport. Is integral component of membrane. Part of voltage-gated Potassium Channel complex. Is expressed in arterial system; sensory organ; skeleton; and tarsus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnmb1 Products (1)

mRNA Protein Name
NM_031169.4 NP_112446.2 calcium-activated potassium channel subunit beta-1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-activated potassium channel activity IGI
IGI: Inferred from genetic interaction
12388098 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16549765 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
12388098 MGI
part of voltage-gated potassium channel complex IGI
IGI: Inferred from genetic interaction
12388098 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calcium-activated potassium channel subunit beta-1

  • BK channel beta subunit

  • BK channel subunit beta-1

  • BKbeta

  • calcium-activated potassium channel subunit beta

  • calcium-activated potassium channel, subfamily M subunit beta-1

  • charybdotoxin receptor subunit beta-1

  • k(VCA)beta-1

  • maxi K channel subunit beta

Kcnmb1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Kcnmb1 Q8CAE3 Kcnma1 Mus musculus Q08460-4
Anti Bait CoIP
16549765
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W396714 Succinic acid sodium Inhibitor / Unkown

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07165 KCNMB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnmb1 NCBI NCBI:3779