Ldb2 - LIM domain binding 2 Gene

Mus musculus

Also known as Ldb3; CLIM1; CLP-36

Gene ID: 16826 | Gene type: protein coding

About Ldb2

Summary

Enables LIM domain binding activity and enzyme binding activity. Involved in regulation of cell migration and regulation of kinase activity. Acts upstream of or within several processes, including epithelial structure maintenance; hair follicle development; and somatic stem cell population maintenance. Located in cell leading edge. Part of transcription regulator complex. Is expressed in several structures, including brain; branchial arch; eye; genitourinary system; and limb. Orthologous to human LDB2 (LIM domain binding 2). [provided by Alliance of Genome Resources, Apr 2022]

Ldb2 Products(6)

mRNA	Protein	Name
NM_001077398.2	NP_001070866.1	LIM domain-binding protein 2 isoform 2
NM_001286348.1	NP_001273277.1	LIM domain-binding protein 2 isoform 3
NM_001347349.1	NP_001334278.1	LIM domain-binding protein 2 isoform 4
NM_001359070.1	NP_001345999.1	LIM domain-binding protein 2 isoform 5
NM_001359071.1	NP_001346000.1	LIM domain-binding protein 2 isoform 6
NM_010698.4	NP_034828.3	LIM domain-binding protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	11882901	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9860983	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cellular component biogenesis	IGI IGI: Inferred from genetic interaction	17991461	MGI
acts upstream of or within epithelial structure maintenance	IGI IGI: Inferred from genetic interaction	17991461	MGI
acts upstream of or within hair follicle development	IGI IGI: Inferred from genetic interaction	17991461	MGI
acts upstream of or within positive regulation of cellular component biogenesis	IGI IGI: Inferred from genetic interaction	17991461	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9192866	MGI
involved in regulation of cell migration	IMP IMP: Inferred from mutant phenotype	19675209	MGI
involved in regulation of kinase activity	IDA IDA: Inferred from direct assay	19675209	MGI
acts upstream of or within somatic stem cell population maintenance	IGI IGI: Inferred from genetic interaction	17991461	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell leading edge	IDA IDA: Inferred from direct assay	19675209	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	9192866	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

LIM domain-binding protein 2

LIM domain-binding factor CLIM1

carboxyl-terminal LIM domain-binding protein 1

Ldb2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ldb2	O55203	Rlim	Mus musculus	Q9WTV7	Pull Down	17848518
Intra	Ldb2	O55203	Rlim	Mus musculus	Q9WTV7	Anti Bait CoIP	17848518

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07569	LDB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ldb2	NCBI	NCBI:9079

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