Lor - loricrin cornified envelope precursor protein Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16939

Summary

A structural constituent of Cytoskeleton and structural constituent of skin epidermis. Predicted to be involved in keratinocyte differentiation and peptide cross-linking. Predicted to act upstream of or within keratinization. Located in cornified envelope and cytoplasmic side of plasma membrane. Is expressed in several structures, including gut; male reproductive system; sensory organ; skin; and thymus. Orthologous to human LORICRIN (loricrin cornified envelope precursor protein). [provided by Alliance of Genome Resources, Apr 2022]

Lor Products (1)

mRNA Protein Name
NM_008508.3 NP_032534.2 loricrin

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables structural constituent of cytoskeleton IDA
IDA: Inferred from direct assay
2190691 MGI
enables structural constituent of skin epidermis IDA
IDA: Inferred from direct assay
2190691 MGI
Cellular Component GO Annotation Evidence References Source
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in cornified envelope IDA
IDA: Inferred from direct assay
2190691 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
2190691 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

loricrin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-16291 APTO-253 99.74% Phase 1
HY-16291A APTO-253 hydrochloride Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-159681 AASS-IN-1 98.40% Unkown
HY-121917 Ro 31-7837 / Unkown
HY-RS07738 LORICRIN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07742 LOXL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown