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Kcnk2 - potassium two pore domain channel subfamily K member 2 Gene

Also Known as Trek-1; rTREK1d

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 170899

Summary

Enables outward rectifier Potassium Channel activity; Potassium Channel Inhibitor activity; and potassium ion leak channel activity. Involved in several processes, including cochlea development; negative regulation of cardiac muscle cell proliferation; and positive regulation of cellular response to hypoxia. Located in several cellular components, including apical plasma membrane; astrocyte projection; and calyx of Held. Is integral component of plasma membrane. Used to study transient cerebral ischemia. Biomarker of brain ischemia; congestive heart failure; myocardial infarction; and transient cerebral ischemia. Orthologous to human KCNK2 (potassium two pore domain channel subfamily K member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnk2 Products (2)

mRNA	Protein	Name
NM_172041.2	NP_742038.2	potassium channel subfamily K member 2 isoform 1
NM_172042.2	NP_742039.1	potassium channel subfamily K member 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ligand-gated channel activity	IDA IDA: Inferred from direct assay	23021213	RGD
enables outward rectifier potassium channel activity	IDA IDA: Inferred from direct assay	11319556	RGD
enables potassium channel inhibitor activity	IDA IDA: Inferred from direct assay	24196565	RGD
enables potassium ion leak channel activity	IDA IDA: Inferred from direct assay	11319556	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16750514	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cardiac ventricle development	IEP IEP: Inferred from expression pattern	24705172	RGD
involved in cellular response to arachidonate	IDA IDA: Inferred from direct assay	26919430	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	24705172	RGD
involved in cochlea development	IEP IEP: Inferred from expression pattern	15094499	RGD
involved in detection of mechanical stimulus involved in sensory perception of touch	IMP IMP: Inferred from mutant phenotype	31630908	RGD
involved in glutamate secretion	IDA IDA: Inferred from direct assay	23021213	RGD
involved in memory	IEP IEP: Inferred from expression pattern	14730890	RGD
involved in negative regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	23271285	RGD
involved in negative regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	24705172	RGD
involved in neuronal action potential	IMP IMP: Inferred from mutant phenotype	31630908	RGD
involved in positive regulation of cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	24705172	RGD
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	11319556	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	10790857	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	17828492	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15261098	RGD
located in astrocyte projection	IDA IDA: Inferred from direct assay	25062759	RGD
located in axon	IDA IDA: Inferred from direct assay	10790857	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	18838117	RGD
located in calyx of Held	IDA IDA: Inferred from direct assay	15261098	RGD
located in cell surface	IDA IDA: Inferred from direct assay	22910181	RGD
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	24196565	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	19571146	RGD
located in node of Ranvier	IDA IDA: Inferred from direct assay	31630908	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	24196565	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	19571146	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
potassium channel subfamily K member 2	TREK-1 K(+) channel subunit arachidonic acid sensitive tandem pore domain potassium channel ion transport membrane protein outward rectifying potassium channel protein TREK-1 potassium channel, two pore domain subfamily K, member 2 stretch-activated

Kcnk2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Kcnk2	Q920B6	GNG4	Homo sapiens	P50150	Anti Tag CoIP	23021213
Cross	Kcnk2	Q920B6	GNG4	Homo sapiens	P50150	Y2H	23021213
Cross	Kcnk2	Q920B6	GNG4	Homo sapiens	P50150	Pull Down	23021213

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1500	2,2,2-Trichloroethanol	Agonist	99.53%	Unkown
HY-RS07158	KCNK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18069	Kcnk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24544	Kcnk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnk2	NCBI	NCBI:3776