GNG4 - G protein subunit gamma 4 Gene

Also Known as HG3C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2786

About GNG4

Cytogenetic location: 1q42.3 Genomic coordinates (GRCh38): 1:235,547,685-235,650,608 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 181 orthologues and 11 paralogues. Biased expression in brain (RPKM 11.8), ovary (RPKM 8.0) and 8 other tissues.

Summary

Predicted to enable G-protein beta-subunit binding activity. Involved in negative regulation of cell growth. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

GNG4 Products (3)

mRNA Protein Name
NM_001098721.2 NP_001092191.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
NM_001098722.2 NP_001092192.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
NM_004485.4 NP_004476.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23021213 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell growth IMP
IMP: Inferred from mutant phenotype
15824735 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNG4 Protein Structure

G-gamma

G-gamma: GGL domain (12 - 75)

  • 0
  • 75 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

  • guanine nucleotide binding protein (G protein), gamma 4

GNG4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GNG4 P50150 FHL2 Homo sapiens Q14192
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS20746 Gng4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05558 GNG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27258 Gng4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GNG4 MGD MGI:102703
Rattus norvegicus GNG4 RGD RGD:620806
Macaca mulatta GNG4 VGNC VGNC:106372
Bos taurus GNG4 VGNC VGNC:29467
Canis familiaris GNG4 VGNC VGNC:51896
Others GNG4 NCBI