Marcks - myristoylated alanine rich protein kinase C substrate Gene

Mus musculus

Also known as Macs; PKCSL

Gene ID: 17118 | Gene type: protein coding

About Marcks

Summary

Enables several functions, including actin filament binding activity; Calmodulin binding activity; and protein kinase C binding activity. Involved in actin crosslink formation and actin filament bundle assembly. Located in several cellular components, including cell cortex; cytoskeleton; and germinal vesicle. Is expressed in several structures, including embryo ectoderm; head skin; nervous system; sensory organ; and tongue mesenchyme. Orthologous to human MARCKS (myristoylated alanine rich protein kinase C substrate). [provided by Alliance of Genome Resources, Apr 2022]

Marcks Products(1)

mRNA	Protein	Name
NM_008538.2	NP_032564.1	myristoylated alanine-rich C-kinase substrate

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IPI IPI: Inferred from physical interaction	15640140	MGI
enables calmodulin binding	EXP EXP: Inferred from Experiment	9468306	MGI
enables calmodulin binding	IDA IDA: Inferred from direct assay	9468306	MGI
enables calmodulin binding	IPI IPI: Inferred from physical interaction	15640140	MGI
enables identical protein binding	IDA IDA: Inferred from direct assay	15640140	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12577052	MGI
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	9857183	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin crosslink formation	IDA IDA: Inferred from direct assay	15640140	MGI
involved in actin filament bundle assembly	IDA IDA: Inferred from direct assay	15640140	MGI
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	30655546	MGI
involved in mitochondrion organization	IDA IDA: Inferred from direct assay	30655546	MGI
involved in neural tube development	IMP IMP: Inferred from mutant phenotype	30655546	MGI
involved in neurogenesis	IMP IMP: Inferred from mutant phenotype	30655546	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	30655546	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin filament bundle	IDA IDA: Inferred from direct assay	15640140	MGI
located in cell cortex	IDA IDA: Inferred from direct assay	15766745	MGI
located in centrosome	IDA IDA: Inferred from direct assay	15766745	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15766745	MGI
located in germinal vesicle	IDA IDA: Inferred from direct assay	15766745	MGI
located in membrane	IDA IDA: Inferred from direct assay	12888215	MGI
is active in organelle	IDA IDA: Inferred from direct assay	30655546	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myristoylated alanine-rich C-kinase substrate

80K protein

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10343	Sotrastaurin		99.79%	Phase 2
HY-106377A	BIO-11006 acetate		99.92%	Phase 2
HY-106377	BIO-11006	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12359	TPPB		99.92%	Unkown
HY-P10218A	MANS peptide TFA		99.88%	Unkown
HY-P10471A	MPSD TFA		99.81%	Unkown
HY-113616A	VU0364572 TFA		98.79%	Unkown
HY-P10218	MANS peptide		99.66%	Unkown
HY-P10471E	MPSD control peptide TFA	Control	95.83%	Unkown
HY-P10471	MPSD		/	Unkown
HY-P10471D	MPSD control peptide	Control	/	Unkown
HY-P10471B	Ala-MPSD		/	Unkown
HY-P5439	Epsilon-V1-2, Cys-conjugated		/	Unkown
HY-113616	VU0364572		/	Unkown
HY-121197	Balanol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Marcks	NCBI	NCBI:4082

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