Marcks - myristoylated alanine rich protein kinase C substrate Gene

Also Known as Macs; PKCSL

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17118

Summary

Enables several functions, including actin filament binding activity; Calmodulin binding activity; and protein kinase C binding activity. Involved in actin crosslink formation and actin filament bundle assembly. Located in several cellular components, including cell cortex; cytoskeleton; and germinal vesicle. Is expressed in several structures, including embryo ectoderm; head skin; nervous system; sensory organ; and tongue mesenchyme. Orthologous to human MARCKS (myristoylated alanine rich protein kinase C substrate). [provided by Alliance of Genome Resources, Apr 2022]

Marcks Products (1)

mRNA Protein Name
NM_008538.2 NP_032564.1 myristoylated alanine-rich C-kinase substrate

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IPI
IPI: Inferred from physical interaction
15640140 MGI
enables calmodulin binding EXP
EXP: Inferred from Experiment
9468306 MGI
enables calmodulin binding IDA
IDA: Inferred from direct assay
9468306 MGI
enables calmodulin binding IPI
IPI: Inferred from physical interaction
15640140 MGI
enables identical protein binding IDA
IDA: Inferred from direct assay
15640140 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12577052 MGI
enables protein kinase C binding IPI
IPI: Inferred from physical interaction
9857183 MGI
Biological Process GO Annotation Evidence References Source
involved in actin crosslink formation IDA
IDA: Inferred from direct assay
15640140 MGI
involved in actin filament bundle assembly IDA
IDA: Inferred from direct assay
15640140 MGI
involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
30655546 MGI
involved in mitochondrion organization IDA
IDA: Inferred from direct assay
30655546 MGI
involved in neural tube development IMP
IMP: Inferred from mutant phenotype
30655546 MGI
involved in neurogenesis IMP
IMP: Inferred from mutant phenotype
30655546 MGI
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
30655546 MGI
Cellular Component GO Annotation Evidence References Source
located in actin filament bundle IDA
IDA: Inferred from direct assay
15640140 MGI
located in cell cortex IDA
IDA: Inferred from direct assay
15766745 MGI
located in centrosome IDA
IDA: Inferred from direct assay
15766745 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15766745 MGI
located in germinal vesicle IDA
IDA: Inferred from direct assay
15766745 MGI
located in membrane IDA
IDA: Inferred from direct assay
12888215 MGI
is active in organelle IDA
IDA: Inferred from direct assay
30655546 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myristoylated alanine-rich C-kinase substrate

  • 80K protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-10343 Sotrastaurin 99.79% Phase 2
HY-106377A BIO-11006 acetate 99.92% Phase 2
HY-106377 BIO-11006 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12359 TPPB 99.92% Unkown
HY-P10218A MANS peptide TFA 99.88% Unkown
HY-P10471A MPSD TFA 99.81% Unkown
HY-113616A VU0364572 TFA 98.79% Unkown
HY-P10218 MANS peptide 99.66% Unkown
HY-P10471E MPSD control peptide TFA Control 95.83% Unkown
HY-P10471 MPSD / Unkown
HY-P10471D MPSD control peptide Control / Unkown
HY-P10471B Ala-MPSD / Unkown
HY-P5439 Epsilon-V1-2, Cys-conjugated / Unkown
HY-113616 VU0364572 / Unkown
HY-121197 Balanol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Marcks NCBI NCBI:4082