Foxe3 - forkhead box E3 Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including camera-type eye development; mRNA transcription by RNA polymerase II; and negative regulation of lens fiber cell differentiation. Predicted to act upstream of or within several processes, including camera-type eye development; positive regulation of epithelial cell proliferation; and transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; anterior segment dysgenesis 2; cataract 34 multiple types; and thoracic aortic aneurysm. Orthologous to human FOXE3 (forkhead box E3). [provided by Alliance of Genome Resources, Apr 2022]