Grip2 - glutamate receptor interacting protein 2 Gene

Rattus norvegicus

Also known as Abp

Gene ID: 171571 | Gene type: protein coding

About Grip2

Summary

Enables glutamate receptor binding activity and protein C-terminus binding activity. Involved in several processes, including positive regulation of AMPA glutamate receptor clustering; positive regulation of excitatory postsynaptic potential; and positive regulation of neuron maturation. Located in several cellular components, including dendritic shaft; neuron spine; and postsynaptic membrane. Is active in postsynaptic density. Orthologous to human GRIP2 (glutamate receptor interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Grip2 Products(1)

mRNA	Protein	Name
NM_138535.2	NP_612544.2	glutamate receptor-interacting protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glutamate receptor binding	IDA IDA: Inferred from direct assay	10436050	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9697854	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of AMPA glutamate receptor clustering	IMP IMP: Inferred from mutant phenotype	20083202	RGD
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	20083202	RGD
involved in positive regulation of neuron maturation	IMP IMP: Inferred from mutant phenotype	20083202	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11978826	RGD
located in dendrite	IDA IDA: Inferred from direct assay	9768844	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	10414981	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	9768844	RGD
located in neuron spine	IDA IDA: Inferred from direct assay	11978826	RGD
located in neuron spine	IMP IMP: Inferred from mutant phenotype	20083202	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	11978826	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	11978826	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	10436050	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	9768844	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	9768844	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	9768844	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate receptor-interacting protein 2

AMPA receptor binding protein	AMPA receptor-interacting protein GRIP2
GRIP-2

Grip2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Grip2	Q9WTW1	Cspg4	Mus musculus	Q8VHY0	Anti Tag CoIP	12458226
Cross	Grip2	Q9WTW1	Cspg4	Mus musculus	Q8VHY0	Y2H	12458226

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05810	GRIP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grip2	NCBI	NCBI:80852

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