Grip2 - glutamate receptor interacting protein 2 Gene

Also Known as Abp

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171571

Summary

Enables glutamate receptor binding activity and protein C-terminus binding activity. Involved in several processes, including positive regulation of AMPA glutamate receptor clustering; positive regulation of excitatory postsynaptic potential; and positive regulation of neuron maturation. Located in several cellular components, including dendritic shaft; neuron spine; and postsynaptic membrane. Is active in postsynaptic density. Orthologous to human GRIP2 (glutamate receptor interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Grip2 Products (1)

mRNA Protein Name
NM_138535.2 NP_612544.2 glutamate receptor-interacting protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutamate receptor binding IDA
IDA: Inferred from direct assay
10436050 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9697854 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of AMPA glutamate receptor clustering IMP
IMP: Inferred from mutant phenotype
20083202 RGD
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
20083202 RGD
involved in positive regulation of neuron maturation IMP
IMP: Inferred from mutant phenotype
20083202 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11978826 RGD
located in dendrite IDA
IDA: Inferred from direct assay
9768844 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
10414981 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
9768844 RGD
located in neuron spine IDA
IDA: Inferred from direct assay
11978826 RGD
located in neuron spine IMP
IMP: Inferred from mutant phenotype
20083202 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11978826 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
11978826 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
10436050 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
9768844 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
9768844 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
9768844 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor-interacting protein 2

  • AMPA receptor binding protein

  • AMPA receptor-interacting protein GRIP2

  • GRIP-2

Grip2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Grip2 Q9WTW1 Cspg4 Mus musculus Q8VHY0
Anti Tag CoIP
12458226
Cross
Grip2 Q9WTW1 Cspg4 Mus musculus Q8VHY0
Y2H
12458226
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05810 GRIP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grip2 NCBI NCBI:80852