Cspg4 - chondroitin sulfate proteoglycan 4 Gene

Also Known as AN2; NG2; Cspg4a; 4732461B14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 121021

Summary

Enables coreceptor activity. Acts upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of MAPK cascade; and ruffle assembly. Located in plasma membrane and ruffle. Is expressed in several structures, including brain; jaw; respiratory system; retina; and skeleton. Human ortholog(s) of this gene implicated in relapsing-remitting multiple sclerosis. Orthologous to human CSPG4 (chondroitin sulfate proteoglycan 4). [provided by Alliance of Genome Resources, Apr 2022]

Cspg4 Products (1)

mRNA Protein Name
NM_139001.2 NP_620570.2 chondroitin sulfate proteoglycan 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables coreceptor activity IDA
IDA: Inferred from direct assay
26437238 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12458226 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within glial cell migration IDA
IDA: Inferred from direct assay
10366628 MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
26437238 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
10036240 MGI
acts upstream of or within ruffle assembly IDA
IDA: Inferred from direct assay
26437238 MGI
acts upstream of or within substrate-dependent cell migration IGI
IGI: Inferred from genetic interaction
26437238 MGI
Cellular Component GO Annotation Evidence References Source
located in cell projection IDA
IDA: Inferred from direct assay
23447615 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11668599 MGI
located in ruffle IDA
IDA: Inferred from direct assay
26437238 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chondroitin sulfate proteoglycan 4

  • AN2 proteoglycan

  • AN2/NG2 proteoglycan

  • chondroitin sulfate proteoglycan NG2

  • nerve/glial antigen 2

  • proteoglycan AN2

Cspg4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cspg4 Q8VHY0 Grip1 Mus musculus Q925T6
Anti Bait CoIP
12458226
Intra
Cspg4 Q8VHY0 Grip1 Mus musculus Q925T6
Y2H Pooling
12458226
Intra
Cspg4 Q8VHY0 Grip1 Mus musculus Q925T6
Anti Tag CoIP
12458226
Intra
Cspg4 Q8VHY0 Gria2 Mus musculus P23819
Anti Bait CoIP
12458226
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS26166 Cspg4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P11838 DOTA-TH10 / Unkown
HY-RS03254 CSPG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19673 Cspg4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cspg4 NCBI NCBI:1464