Grip1 - glutamate receptor interacting protein 1 Gene

Also Known as eb; GRIP; 4931400F03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74053

Summary

This gene encodes a protein containing multiple PDZ (post synaptic density protein, Drosophila disc large tumor suppressor, and zonula occludens-1 protein) domains. The encoded protein acts as a mediator between cytoskeletal and membrane proteins, particularly in neuronal cells, and facilitates complex formation at the cell membrane. Mutation of this gene can cause embryonic lethality resulting from defects of the dermo-epidermal junction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Grip1 Products (10)

mRNA Protein Name
NM_001277292.1 NP_001264221.1 glutamate receptor-interacting protein 1 isoform 4
NM_001277293.1 NP_001264222.1 glutamate receptor-interacting protein 1 isoform 5
NM_001277294.1 NP_001264223.1 glutamate receptor-interacting protein 1 isoform 6
NM_001277295.1 NP_001264224.1 glutamate receptor-interacting protein 1 isoform 7
NM_001358809.1 NP_001345738.1 glutamate receptor-interacting protein 1 isoform 8
NM_001358810.1 NP_001345739.1 glutamate receptor-interacting protein 1 isoform 9
NM_001358811.1 NP_001345740.1 glutamate receptor-interacting protein 1 isoform 10
NM_028736.2 NP_083012.1 glutamate receptor-interacting protein 1 isoform 1
NM_130891.2 NP_570961.1 glutamate receptor-interacting protein 1 isoform 2
NM_133442.2 NP_597699.1 glutamate receptor-interacting protein 1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9883737 MGI
Biological Process GO Annotation Evidence References Source
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane IDA
IDA: Inferred from direct assay
20956289 MGI
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane IEP
IEP: Inferred from expression pattern
20956289 MGI
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane IMP
IMP: Inferred from mutant phenotype
20956289 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
14730302 MGI
involved in vesicle-mediated transport in synapse IDA
IDA: Inferred from direct assay
20956289 MGI
involved in vesicle-mediated transport in synapse IEP
IEP: Inferred from expression pattern
20956289 MGI
involved in vesicle-mediated transport in synapse IMP
IMP: Inferred from mutant phenotype
20956289 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20956289 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
20956289 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
20956289 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
10197531 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
15207857 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15207857 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor-interacting protein 1

  • eye blebs

Grip1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Grip1 Q925T6 Vdr Mus musculus P48281
Y2H
12529369
Intra
Grip1 Q925T6 Ephb2 Mus musculus P54763
Pull Down
9883737
Intra
Grip1 Q925T6 Gria2 Mus musculus P23819
Anti Bait CoIP
12458226
Intra
Grip1 Q925T6 Cspg4 Mus musculus Q8VHY0
Anti Bait CoIP
12458226
Intra
Grip1 Q925T6 Cspg4 Mus musculus Q8VHY0
Anti Tag CoIP
12458226
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09090 NCOA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05809 GRIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19007 Grip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19721 Ncoa2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25496 Grip1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26217 Ncoa2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grip1 NCBI NCBI:23426