Mmp24 - matrix metallopeptidase 24 Gene

Also Known as MMP-21; MT5MMP; MTMMP5; MT5-MMP

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17391

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein do not develop neuropathic pain with mechanical allodynia after sciatic nerve injury, display enhanced sensitivity to noxious thermal stimuli under basal conditions, and develop hyperalgesia during inflammation. [provided by RefSeq, Feb 2016]

Mmp24 Products (1)

mRNA Protein Name
NM_010808.4 NP_034938.3 matrix metalloproteinase-24 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cadherin binding IPI
IPI: Inferred from physical interaction
24952463 MGI
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
24952463 MGI
Biological Process GO Annotation Evidence References Source
involved in cell-cell adhesion mediated by cadherin IDA
IDA: Inferred from direct assay
24952463 MGI
involved in cell-cell adhesion via plasma-membrane adhesion molecules IMP
IMP: Inferred from mutant phenotype
19805319 MGI
involved in detection of temperature stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
19805319 MGI
involved in glial cell differentiation IDA
IDA: Inferred from direct assay
24952463 MGI
involved in neuronal stem cell population maintenance IDA
IDA: Inferred from direct assay
24952463 MGI
involved in proteolysis IMP
IMP: Inferred from mutant phenotype
19805319 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
14990567 MGI
located in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
14990567 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

matrix metalloproteinase-24

  • matrix metalloproteinase-21

  • membrane type 5-MMP

  • membrane-type matrix metalloproteinase 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-184183 MT5-MMP-IN-1 Inhibitor / Unkown
HY-RS08543 MMP24 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp24 NCBI NCBI:10893