Nup62 - nucleoporin 62 Gene

Also Known as p62; Nupc1; D7Ertd649e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18226

Summary

Enables HSP70 protein binding activity; HSP90 protein binding activity; and PTB domain binding activity. Involved in negative regulation of cell population proliferation and negative regulation of signal transduction. Acts upstream of or within cell aging. Located in nuclear membrane. Part of nuclear pore. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and integumental system. Human ortholog(s) of this gene implicated in primary biliary cholangitis and striatonigral degeneration. Orthologous to human NUP62 (nucleoporin 62). [provided by Alliance of Genome Resources, Apr 2022]

Nup62 Products (1)

mRNA Protein Name
NM_053074.2 NP_444304.1 nuclear pore glycoprotein p62

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp70 protein binding IDA
IDA: Inferred from direct assay
19581287 MGI
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
19581287 MGI
enables PTB domain binding IPI
IPI: Inferred from physical interaction
11031258 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19581287 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular senescence IDA
IDA: Inferred from direct assay
15572682 MGI
involved in negative regulation of MAP kinase activity IMP
IMP: Inferred from mutant phenotype
11489947 MGI
involved in negative regulation of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
11489947 MGI
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11489947 MGI
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11489947 MGI
Cellular Component GO Annotation Evidence References Source
located in nuclear membrane IDA
IDA: Inferred from direct assay
22683860 MGI
part of nuclear pore IDA
IDA: Inferred from direct assay
1915419 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear pore glycoprotein p62

  • 62 kDa nucleoporin

  • nuclear pore complex 1

  • nucleoporin Nup62

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W039939 2-Azido-2-deoxy-D-glucose, 98% Substrate 98.0% Unkown
HY-RS09697 NUP62 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nup62 NCBI NCBI:23636