Stra8 - stimulated by retinoic acid gene 8 Gene

Mus musculus

Gene ID: 20899 | Gene type: protein coding

About Stra8

Summary

Involved in several processes, including activation of meiosis; cellular response to retinoic acid; and germ cell development. Located in cytoplasm and nucleus. Is expressed in central nervous system; ganglia; gonad; spleen primordium; and trophoblast giant cell. Orthologous to human STRA8 (stimulated by retinoic acid 8). [provided by Alliance of Genome Resources, Apr 2022]

Stra8 Products(3)

mRNA	Protein	Name
NM_001410379.1	NP_001397308.1	stimulated by retinoic acid gene 8 protein isoform 2
NM_001410380.1	NP_001397309.1	stimulated by retinoic acid gene 8 protein isoform 3
NM_009292.3	NP_033318.1	stimulated by retinoic acid gene 8 protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22674187	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of meiosis	IMP IMP: Inferred from mutant phenotype	32032549	MGI
involved in cellular response to retinoic acid	IMP IMP: Inferred from mutant phenotype	19301398	MGI
involved in male germ-line stem cell asymmetric division	IMP IMP: Inferred from mutant phenotype	25902548	MGI
involved in meiotic cell cycle	IMP IMP: Inferred from mutant phenotype	32032549	MGI
involved in oogenesis	IMP IMP: Inferred from mutant phenotype	32032549	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19805549	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	32032549	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	32032549	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8896602	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	25972016	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19805549	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

stimulated by retinoic acid gene 8 protein

Stra8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Stra8	P70278	Arid4b	Mus musculus	A2CG63	Y2H	22674187

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W011094	Win 18446	Inhibitor	98.94%	Unkown
HY-RS13958	STRA8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stra8	NCBI	NCBI:346673

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