STRA8 - stimulated by retinoic acid 8 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 346673

About STRA8

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:135,231,915-135,258,663 (from NCBI)

This gene has 3 transcripts (splice variants) and 133 orthologues. Low expression observed in reference dataset.

Summary

This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]

STRA8 Products (2)

mRNA Protein Name
NM_001394401.1 NP_001381330.1 stimulated by retinoic acid gene 8 protein homolog isoform 1
NM_182489.3 NP_872295.2 stimulated by retinoic acid gene 8 protein homolog isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22899867 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

stimulated by retinoic acid gene 8 protein homolog

STRA8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STRA8 Q7Z7C7 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
STRA8 Q7Z7C7 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
STRA8 Q7Z7C7 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
STRA8 Q7Z7C7 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra
STRA8 Q7Z7C7 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra
STRA8 Q7Z7C7 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
STRA8 Q7Z7C7 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
STRA8 Q7Z7C7 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
STRA8 Q7Z7C7 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
STRA8 Q7Z7C7 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
STRA8 Q7Z7C7 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
STRA8 Q7Z7C7 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
STRA8 Q7Z7C7 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra
STRA8 Q7Z7C7 SERTAD2 Homo sapiens Q14140
Y2H Array
32296183
Intra
STRA8 Q7Z7C7 SERTAD2 Homo sapiens Q14140
Y2H Prey Pooling
32296183
Intra
STRA8 Q7Z7C7 CTDSP1 Homo sapiens Q9GZU7
Validated Y2H
32296183
Intra
STRA8 Q7Z7C7 CTDSP1 Homo sapiens Q9GZU7
Y2H Array
32296183
Intra
STRA8 Q7Z7C7 CTDSP1 Homo sapiens Q9GZU7
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spastic Paraplegia 24, Autosomal Recessive

  • SPG24

  • Spastic Paraplegia 24

  • Hereditary Spastic Paraplegia 24

  • Autosomal Recessive Spastic Paraplegia Type 24

  • Autosomal Recessive Spastic Paraplegia 24
Spermatogenic Failure, X-Linked, 1

  • Sertoli Cell-Only Syndrome

  • Germinal Cell Aplasia

  • Del Castillo Syndrome

  • SPGFX1

  • X-Linked Spermatogenic Failure 1

  • Congenital Absence Of Germinal Epithelium Of Testes
Hereditary Spastic Paraplegia 56

  • Autosomal Recessive Spastic Paraplegia Type 56

  • Spg56

  • Autosomal Recessive Spastic Paraplegia 56
Spermatocytoma

  • Spermatocytic Seminoma
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Testicular Disease

  • Testicular Dysfunction

  • Testicular Diseases

  • Disorder Of Testis

  • Testis Disorder

  • Testicular Disorders
Testicular Germ Cell Cancer

  • Germ Cell Tumor Of Testis

  • Testicular Germ Cell Tumor

  • Testicular Germ Cell Neoplasm

  • Testicular Malignant Germ Cell Tumor
Cryptorchidism, Unilateral Or Bilateral

  • Cryptorchidism

  • Undescended Testicle

  • Undescended Testis

  • Cryptorchism

  • Undescended Testicles

  • CRYPTO

  • Impaired Testicular Descent

  • Cryptosporidiosis

  • Retained Testis

  • Unilateral Cryptorchidism

  • Unilateral Undescended Testis

  • Nondescent Unilateral Testicle

  • Unilateral Cryptorchism

  • Ectopic Testis, Unilateral

  • Bilateral Cryptorchidism

  • Bilateral Cryptorchism

  • Bilateral Nondescent Testicle

  • Bilateral Undescended Testes

  • Bilateral Ectopic Testes
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Testicular Cancer

  • Testis Cancer

  • Testicular Carcinoma

  • Testicular Neoplasms

  • Malignant Neoplasm Of Testis

  • Childhood Neoplasm Of The Testis

  • Neoplasm Of Testis

  • Pediatric Testicular Neoplasm

  • Testicular Tumor

  • Testis Neoplasm

  • Testicular Tumors

  • Testicular Neoplasm

  • Testicular Malignant Germ Cell Tumor

  • Childhood Testicular Neoplasm

  • Carcinoma Of The Testis

  • Cancer Of Testis

  • Malignant Neoplasm Of Testis, Nos

  • Malignant Neoplasm Of Testis, Unspecified

  • Malignant Tumour Of Testis

  • Testicle Cancer

  • Primary Malignant Neoplasm Of Testis
Disorder Of Sexual Development

  • Disorder Of Sex Development

  • Disorders Of Sex Development

  • Sex Development Disorder

  • Sex Differentiation Disease

  • Dsd

  • Sex Differentiation Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W011094 Win 18446 Inhibitor 98.94% Unkown
HY-RS13958 STRA8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus STRA8 VGNC VGNC:65800
Rattus norvegicus STRA8 RGD RGD:1562852
Bos taurus STRA8 VGNC VGNC:53678
Canis familiaris STRA8 VGNC VGNC:46938
Mus musculus STRA8 MGD MGI:107917
Macaca mulatta STRA8 VGNC VGNC:78250
Others STRA8 NCBI