2. Gene
  3. Aldh1l2 - aldehyde dehydrogenase 1 family, member L2 Gene

Aldh1l2 - aldehyde dehydrogenase 1 family, member L2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as mtFDH; D330038I09Rik

Gene ID: 216188 | Gene type: protein coding

About Aldh1l2

Summary

Predicted to enable aldehyde dehydrogenase (NAD+) activity and formyltetrahydrofolate dehydrogenase activity. Predicted to be involved in 10-formyltetrahydrofolate catabolic process; biosynthetic process; and one-carbon metabolic process. Located in mitochondrion. Used to study non-alcoholic fatty liver disease. Orthologous to human ALDH1L2 (aldehyde dehydrogenase 1 family member L2). [provided by Alliance of Genome Resources, Apr 2022]

Aldh1l2 Products(1)

mRNA Protein Name
NM_153543.2 NP_705771.2 mitochondrial 10-formyltetrahydrofolate dehydrogenase
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables formyltetrahydrofolate dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
33168096 MGI
Biological Process GO Annotation Evidence Reference Source
involved in 10-formyltetrahydrofolate catabolic process IMP
IMP: Inferred from mutant phenotype
33168096 MGI
involved in NADPH regeneration IMP
IMP: Inferred from mutant phenotype
33168096 MGI
acts upstream of or within positive effect fatty acid beta-oxidation IMP
IMP: Inferred from mutant phenotype
33168096 MGI
involved in folic acid metabolic process IMP
IMP: Inferred from mutant phenotype
33168096 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial 10-formyltetrahydrofolate dehydrogenase

aldehyde dehydrogenase 1L2

aldehyde dehydrogenase family 1 member L2, mitochondrial

mitochondrial 10-FTHFDH

probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W011094 Win 18446 Inhibitor 98.94% Unkown
HY-122912 ALDH1A inhibitor 673A 99.15% Unkown
HY-125085 ALDH3A1-IN-3 Inhibitor 99.43% Unkown
HY-135841 CM010 Inhibitor 99.70% Unkown
HY-139031 ALDH1A2-IN-1 Inhibitor 98.05% Unkown
HY-139032 CM121 Inhibitor / Unkown
HY-157567 FSI-TN42 Inhibitor 98.05% Unkown
HY-158026 ALDH1A1-IN-5 Inhibitor / Unkown
HY-RS00563 ALDH1A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00567 ALDH1L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17028 Aldh1a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23472 Aldh1a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aldh1l2 NCBI NCBI:160428