Aldh1l2 - aldehyde dehydrogenase 1 family, member L2 Gene

Also Known as mtFDH; D330038I09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 216188

Summary

Predicted to enable aldehyde dehydrogenase (NAD+) activity and formyltetrahydrofolate dehydrogenase activity. Predicted to be involved in 10-formyltetrahydrofolate catabolic process; biosynthetic process; and one-carbon metabolic process. Located in mitochondrion. Used to study non-alcoholic fatty liver disease. Orthologous to human ALDH1L2 (aldehyde dehydrogenase 1 family member L2). [provided by Alliance of Genome Resources, Apr 2022]

Aldh1l2 Products (1)

mRNA Protein Name
NM_153543.2 NP_705771.2 mitochondrial 10-formyltetrahydrofolate dehydrogenase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables formyltetrahydrofolate dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
33168096 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in 10-formyltetrahydrofolate catabolic process IMP
IMP: Inferred from mutant phenotype
33168096 MGI
involved in NADPH regeneration IMP
IMP: Inferred from mutant phenotype
33168096 MGI
acts upstream of or within positive effect fatty acid beta-oxidation IMP
IMP: Inferred from mutant phenotype
33168096 MGI
involved in folic acid metabolic process IMP
IMP: Inferred from mutant phenotype
33168096 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial 10-formyltetrahydrofolate dehydrogenase

  • aldehyde dehydrogenase 1L2

  • aldehyde dehydrogenase family 1 member L2, mitochondrial

  • mitochondrial 10-FTHFDH

  • probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-W011094 Win 18446 Inhibitor 98.94% Unkown
HY-125085 ALDH3A1-IN-3 Inhibitor 99.43% Unkown
HY-122912 ALDH1A inhibitor 673A 99.15% Unkown
HY-135841 CM010 Inhibitor 99.70% Unkown
HY-139031 ALDH1A2-IN-1 Inhibitor 98.05% Unkown
HY-157567 FSI-TN42 Inhibitor 98.05% Unkown
HY-139032 CM121 Inhibitor / Unkown
HY-158026 ALDH1A1-IN-5 Inhibitor / Unkown
HY-RS00563 ALDH1A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00567 ALDH1L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17028 Aldh1a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23472 Aldh1a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aldh1l2 NCBI NCBI:160428