Wnt7a - wingless-type MMTV integration site family, member 7A Gene

Also Known as px; tw; Wnt-7a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22421

Summary

Enables Frizzled binding activity. Involved in several processes, including dendritic spine morphogenesis; modulation of chemical synaptic transmission; and reproductive structure development. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and embryonic limb morphogenesis. Located in cell surface; extracellular matrix; and glutamatergic synapse. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; reproductive system; and sensory organ. Used to study Fuhrmann syndrome. Human ortholog(s) of this gene implicated in Fuhrmann syndrome and Schinzel type phocomelia. Orthologous to human WNT7A (Wnt family member 7A). [provided by Alliance of Genome Resources, Apr 2022]

Wnt7a Products (2)

mRNA Protein Name
NM_001363757.1 NP_001350686.1 protein Wnt-7a isoform 2 precursor
NM_009527.4 NP_033553.2 protein Wnt-7a isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables frizzled binding IPI
IPI: Inferred from physical interaction
19497282 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10866835 MGI
Biological Process GO Annotation Evidence References Source
involved in Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
21670302 MGI
acts upstream of or within angiogenesis IGI
IGI: Inferred from genetic interaction
19129494 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
15070830 MGI
acts upstream of or within asymmetric protein localization involved in cell fate determination IDA
IDA: Inferred from direct assay
19497282 MGI
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
12937339 MGI
acts upstream of or within canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19023080 MGI
involved in cartilage development IDA
IDA: Inferred from direct assay
16826533 MGI
acts upstream of or within central nervous system vasculogenesis IGI
IGI: Inferred from genetic interaction
19023080 MGI
acts upstream of or within cerebellar granule cell differentiation IDA
IDA: Inferred from direct assay
9405095 MGI
involved in dendritic spine morphogenesis IGI
IGI: Inferred from genetic interaction
21670302 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
7885472 MGI
acts upstream of or within embryonic forelimb morphogenesis IGI
IGI: Inferred from genetic interaction
9362463 MGI
acts upstream of or within embryonic hindlimb morphogenesis IGI
IGI: Inferred from genetic interaction
15880584 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: Inferred from genetic interaction
15242796 MGI
acts upstream of or within establishment of blood-brain barrier IGI
IGI: Inferred from genetic interaction
30478038 MGI
acts upstream of or within establishment of cell polarity IDA
IDA: Inferred from direct assay
19497282 MGI
involved in limb development IDA
IDA: Inferred from direct assay
16826533 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15070830 MGI
acts upstream of or within neurotransmitter secretion IGI
IGI: Inferred from genetic interaction
16818724 MGI
acts upstream of or within non-canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19497282 MGI
involved in oviduct development IMP
IMP: Inferred from mutant phenotype
14695376 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12937339 MGI
acts upstream of or within positive regulation of endothelial cell migration IDA
IDA: Inferred from direct assay
19129494 MGI
involved in positive regulation of excitatory postsynaptic potential IGI
IGI: Inferred from genetic interaction
21670302 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
19129494 MGI
acts upstream of or within positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
9405095 MGI
acts upstream of or within regulation of axon diameter IDA
IDA: Inferred from direct assay
9405095 MGI
acts upstream of or within regulation of axonogenesis IDA
IDA: Inferred from direct assay
9405095 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15070830 MGI
acts upstream of or within regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15070830 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
21670302 MGI
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
21670302 MGI
involved in regulation of synaptic vesicle exocytosis EXP
EXP: Inferred from Experiment
26400647 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
26400647 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
26400647 MGI
acts upstream of or within response to estrogen IMP
IMP: Inferred from mutant phenotype
15070830 MGI
acts upstream of or within skeletal muscle satellite cell activation IDA
IDA: Inferred from direct assay
19497282 MGI
acts upstream of or within skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IDA
IDA: Inferred from direct assay
19497282 MGI
acts upstream of or within somatic stem cell division IDA
IDA: Inferred from direct assay
19497282 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
19497282 MGI
acts upstream of synapse assembly IDA
IDA: Inferred from direct assay
9405095 MGI
acts upstream of or within synapse organization IGI
IGI: Inferred from genetic interaction
16818724 MGI
acts upstream of or within synapse organization IMP
IMP: Inferred from mutant phenotype
16818724 MGI
acts upstream of or within uterus development IMP
IMP: Inferred from mutant phenotype
15070830 MGI
involved in uterus morphogenesis IMP
IMP: Inferred from mutant phenotype
14695376 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
26400647 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
26400647 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
26400647 MGI
located in cell surface IDA
IDA: Inferred from direct assay
8167409 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
8167409 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21670302 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21670302 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Wnt-7a

  • postaxial hemimelia

  • wingless-related MMTV integration site 7A

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-105634A Nomegestrol acetate Agonist 99.73% Yes

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D1474 WNT7A-IN-1 sodium Inhibitor 98.05% Unkown
HY-170411 WNT7A-IN-1 Inhibitor 99.66% Unkown
HY-181160 JNK3/Wnt/β-catenin modulator-1 / Unkown
HY-RS15840 WNT7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wnt7a NCBI NCBI:7476