Wnt7a - wingless-type MMTV integration site family, member 7A Gene

Mus musculus

Also known as px; tw; Wnt-7a

Gene ID: 22421 | Gene type: protein coding

About Wnt7a

Summary

Enables Frizzled binding activity. Involved in several processes, including dendritic spine morphogenesis; modulation of chemical synaptic transmission; and reproductive structure development. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and embryonic limb morphogenesis. Located in cell surface; extracellular matrix; and glutamatergic synapse. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; reproductive system; and sensory organ. Used to study Fuhrmann syndrome. Human ortholog(s) of this gene implicated in Fuhrmann syndrome and Schinzel type phocomelia. Orthologous to human WNT7A (Wnt family member 7A). [provided by Alliance of Genome Resources, Apr 2022]

Wnt7a Products(2)

mRNA	Protein	Name
NM_001363757.1	NP_001350686.1	protein Wnt-7a isoform 2 precursor
NM_009527.4	NP_033553.2	protein Wnt-7a isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables frizzled binding	IPI IPI: Inferred from physical interaction	19497282	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10866835	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	21670302	MGI
acts upstream of or within angiogenesis	IGI IGI: Inferred from genetic interaction	19129494	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	15070830	MGI
acts upstream of or within asymmetric protein localization involved in cell fate determination	IDA IDA: Inferred from direct assay	19497282	MGI
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	12937339	MGI
acts upstream of or within canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	19023080	MGI
involved in cartilage development	IDA IDA: Inferred from direct assay	16826533	MGI
acts upstream of or within central nervous system vasculogenesis	IGI IGI: Inferred from genetic interaction	19023080	MGI
acts upstream of or within cerebellar granule cell differentiation	IDA IDA: Inferred from direct assay	9405095	MGI
involved in dendritic spine morphogenesis	IGI IGI: Inferred from genetic interaction	21670302	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	7885472	MGI
acts upstream of or within embryonic forelimb morphogenesis	IGI IGI: Inferred from genetic interaction	9362463	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IGI IGI: Inferred from genetic interaction	15880584	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	15242796	MGI
acts upstream of or within establishment of blood-brain barrier	IGI IGI: Inferred from genetic interaction	30478038	MGI
acts upstream of or within establishment of cell polarity	IDA IDA: Inferred from direct assay	19497282	MGI
involved in limb development	IDA IDA: Inferred from direct assay	16826533	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15070830	MGI
acts upstream of or within neurotransmitter secretion	IGI IGI: Inferred from genetic interaction	16818724	MGI
acts upstream of or within non-canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	19497282	MGI
involved in oviduct development	IMP IMP: Inferred from mutant phenotype	14695376	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12937339	MGI
acts upstream of or within positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	19129494	MGI
involved in positive regulation of excitatory postsynaptic potential	IGI IGI: Inferred from genetic interaction	21670302	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	19129494	MGI
acts upstream of or within positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	9405095	MGI
acts upstream of or within regulation of axon diameter	IDA IDA: Inferred from direct assay	9405095	MGI
acts upstream of or within regulation of axonogenesis	IDA IDA: Inferred from direct assay	9405095	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15070830	MGI
acts upstream of or within regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15070830	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	21670302	MGI
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	21670302	MGI
involved in regulation of synaptic vesicle exocytosis	EXP EXP: Inferred from Experiment	26400647	MGI
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	26400647	MGI
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	26400647	MGI
acts upstream of or within response to estrogen	IMP IMP: Inferred from mutant phenotype	15070830	MGI
acts upstream of or within skeletal muscle satellite cell activation	IDA IDA: Inferred from direct assay	19497282	MGI
acts upstream of or within skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	IDA IDA: Inferred from direct assay	19497282	MGI
acts upstream of or within somatic stem cell division	IDA IDA: Inferred from direct assay	19497282	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	19497282	MGI
acts upstream of synapse assembly	IDA IDA: Inferred from direct assay	9405095	MGI
acts upstream of or within synapse organization	IGI IGI: Inferred from genetic interaction	16818724	MGI
acts upstream of or within synapse organization	IMP IMP: Inferred from mutant phenotype	16818724	MGI
acts upstream of or within uterus development	IMP IMP: Inferred from mutant phenotype	15070830	MGI
involved in uterus morphogenesis	IMP IMP: Inferred from mutant phenotype	14695376	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	EXP EXP: Inferred from Experiment	26400647	MGI
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	26400647	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	26400647	MGI
located in cell surface	IDA IDA: Inferred from direct assay	8167409	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	8167409	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21670302	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21670302	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein Wnt-7a

postaxial hemimelia

wingless-related MMTV integration site 7A

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-105634A	Nomegestrol acetate	Agonist	99.73%	Yes

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D1474	WNT7A-IN-1 sodium	Inhibitor	98.05%	Unkown
HY-170411	WNT7A-IN-1	Inhibitor	99.66%	Unkown
HY-181160	JNK3/Wnt/β-catenin modulator-1		/	Unkown
HY-RS15840	WNT7A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wnt7a	NCBI	NCBI:7476

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