Zfp42 - zinc finger protein 42 Gene

Also Known as Rex1; Rex-1; Zfp-42

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22702

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of genetic imprinting; and spermatid development. Located in cytoplasm and nucleus. Part of protein-containing complex. Is expressed in early conceptus; gonad; tail; and ureter. Orthologous to human ZFP42 (ZFP42 Zinc Finger Protein). [provided by Alliance of Genome Resources, Apr 2022]

Zfp42 Products (1)

mRNA	Protein	Name
NM_009556.3	NP_033582.2	zinc finger protein 42

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	18237746	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	17478514	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21530438	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21530438	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
acts upstream of or within genomic imprinting	IMP IMP: Inferred from mutant phenotype	21233130	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	21233130	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18237746	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	21641340	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21530438	MGI
located in nucleus	IDA IDA: Inferred from direct assay	21530438	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	21530438	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
zinc finger protein 42	mREX-1 reduced expression protein 1

Zfp42 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Zfp42	P22227	Rlim	Mus musculus	Q9WTV7	Anti Tag CoIP	22596162

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16043	ZFP42 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zfp42	NCBI	NCBI:132625