Lingo1 - leucine rich repeat and Ig domain containing 1 Gene

Also Known as LERN1; Lrrn6a; UNQ201; LINGO-1; 4930471K13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 235402

Summary

Enables epidermal growth factor receptor binding activity. Acts upstream of or within generation of neurons and protein kinase B signaling. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including branchial arch; central nervous system; gut; sensory organ; and somite. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and glaucoma. Orthologous to human LINGO1 (leucine rich repeat and Ig domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Lingo1 Products (8)

mRNA Protein Name
NM_001311076.1 NP_001298005.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 1 precursor
NM_001361115.1 NP_001348044.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor
NM_001361116.1 NP_001348045.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor
NM_001361117.1 NP_001348046.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor
NM_001361118.1 NP_001348047.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor
NM_001361119.1 NP_001348048.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor
NM_001361120.1 NP_001348049.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor
NM_181074.5 NP_851419.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables epidermal growth factor receptor binding IPI
IPI: Inferred from physical interaction
17726113 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15695332 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within central nervous system neuron development IDA
IDA: Inferred from direct assay
17726113 MGI
acts upstream of or within central nervous system neuron development IMP
IMP: Inferred from mutant phenotype
17726113 MGI
acts upstream of or within negative regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
15895088 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
17726113 MGI
acts upstream of or within neuron projection development IDA
IDA: Inferred from direct assay
17726113 MGI
acts upstream of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
15895088 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
31171447 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
31171447 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

  • leucine-rich repeat neuronal protein 1

  • leucine-rich repeat neuronal protein 6A

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99780 Opicinumab Antagonist 99.64% Phase 2

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07680 LINGO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lingo1 NCBI NCBI:84894