CYP4A11 - Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 Gene

Also Known as Cyp4a11

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24306

Summary

Enables alkane 1-monooxygenase activity; arachidonic acid binding activity; and arachidonic acid monooxygenase activity. Involved in several processes, including fatty acid metabolic process; icosanoid biosynthetic process; and response to hormone. Located in intracellular membrane-bounded organelle. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (Cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (Cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Apr 2022]

CYP4A11 Products (1)

mRNA Protein Name
NM_001044770.2 NP_001038235.1 cytochrome P450 4A2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables alkane 1-monooxygenase activity IMP
IMP: Inferred from mutant phenotype
12857783 RGD
enables arachidonate binding IDA
IDA: Inferred from direct assay
10620324 RGD
enables arachidonate monooxygenase activity IMP
IMP: Inferred from mutant phenotype
12857783 RGD
enables fatty acid binding IDA
IDA: Inferred from direct assay
10620324 RGD
Biological Process GO Annotation Evidence References Source
involved in arachidonate metabolic process IMP
IMP: Inferred from mutant phenotype
12857783 RGD
involved in icosanoid biosynthetic process IMP
IMP: Inferred from mutant phenotype
12857783 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
9281597 RGD
involved in lauric acid metabolic process IDA
IDA: Inferred from direct assay
10362749 RGD
involved in linoleic acid metabolic process IDA
IDA: Inferred from direct assay
10362749 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
8274152 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
7980643 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450 4A2

  • CYPIVA2

  • P-450 IV4AII

  • P-450 K-2

  • P450 K-5

  • P450-LA-omega 2

  • cytochrome P-450 K-2

  • cytochrome P450 4A2-like

  • cytochrome P450 K-5

  • cytochrome P450, subfamily 4A, polypeptide 11

  • cytochrome P450, subfamily IVA, polypeptide 11

  • cytochrome P450-LA-omega 2

  • la

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156876 20-HETE inhibitor-2 Inhibitor 99.17% Unkown
HY-151810 TP0472993 Inhibitor 98.22% Unkown
HY-151809 CYP4A11/CYP4F2-IN-1 Inhibitor 99.82% Unkown
HY-124084A SW203668 TFA Inhibitor 99.79% Unkown
HY-124084 SW203668 Inhibitor / Unkown
HY-149770 CYP4A11/CYP4F2-IN-2 Inhibitor / Unkown
HY-RS03476 CYP4A11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03478 CYP4F11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W472509 11-HETE Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CYP4A11 NCBI NCBI:1579