CYP4A11 - Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 Gene

Rattus norvegicus

Also known as Cyp4a11

Gene ID: 24306 | Gene type: protein coding

About CYP4A11

Summary

Enables alkane 1-monooxygenase activity; arachidonic acid binding activity; and arachidonic acid monooxygenase activity. Involved in several processes, including fatty acid metabolic process; icosanoid biosynthetic process; and response to hormone. Located in intracellular membrane-bounded organelle. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (Cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (Cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Apr 2022]

CYP4A11 Products(1)

mRNA	Protein	Name
NM_001044770.2	NP_001038235.1	cytochrome P450 4A2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables alkane 1-monooxygenase activity	IMP IMP: Inferred from mutant phenotype	12857783	RGD
enables arachidonate binding	IDA IDA: Inferred from direct assay	10620324	RGD
enables arachidonate monooxygenase activity	IMP IMP: Inferred from mutant phenotype	12857783	RGD
enables fatty acid binding	IDA IDA: Inferred from direct assay	10620324	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in arachidonate metabolic process	IMP IMP: Inferred from mutant phenotype	12857783	RGD
involved in icosanoid biosynthetic process	IMP IMP: Inferred from mutant phenotype	12857783	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	9281597	RGD
involved in lauric acid metabolic process	IDA IDA: Inferred from direct assay	10362749	RGD
involved in linoleic acid metabolic process	IDA IDA: Inferred from direct assay	10362749	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	8274152	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	7980643	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytochrome P450 4A2

CYPIVA2	P-450 IV4AII
P-450 K-2	P450 K-5
P450-LA-omega 2	cytochrome P-450 K-2
cytochrome P450 4A2-like	cytochrome P450 K-5
cytochrome P450, subfamily 4A, polypeptide 11	cytochrome P450, subfamily IVA, polypeptide 11
cytochrome P450-LA-omega 2	la

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156876	20-HETE inhibitor-2	Inhibitor	99.17%	Unkown
HY-151810	TP0472993	Inhibitor	98.22%	Unkown
HY-151809	CYP4A11/CYP4F2-IN-1	Inhibitor	99.82%	Unkown
HY-124084A	SW203668 TFA	Inhibitor	99.79%	Unkown
HY-124084	SW203668	Inhibitor	/	Unkown
HY-149770	CYP4A11/CYP4F2-IN-2	Inhibitor	/	Unkown
HY-RS03476	CYP4A11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03478	CYP4F11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W472509	11-HETE	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	CYP4A11	NCBI	NCBI:1579

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