CYP4A11 - cytochrome P450 family 4 subfamily A member 11 Gene

Also Known as CP4Y; CYP4A2; CYP4AII; CYPIVA11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1579

About CYP4A11

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:46,929,188-46,941,476 (from NCBI)

This gene has 8 transcripts (splice variants), 376 orthologues and 12 paralogues. Biased expression in liver (RPKM 280.4) and kidney (RPKM 130.2).

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

CYP4A11 Products (3)

mRNA Protein Name
NM_000778.4 NP_000769.2 cytochrome P450 4A11 isoform 1
NM_001319155.2 NP_001306084.1 cytochrome P450 4A11 isoform 2
NM_001363587.2 NP_001350516.1 cytochrome P450 4A11 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alkane 1-monooxygenase activity IDA
IDA: Inferred from direct assay
18433732 GOA
enables arachidonate epoxygenase activity IDA
IDA: Inferred from direct assay
9618440 GOA
enables leukotriene-B4 20-monooxygenase activity IDA
IDA: Inferred from direct assay
9799565 GOA
enables long-chain fatty acid omega-hydroxylase activity IDA
IDA: Inferred from direct assay
15145985 GOA
Biological Process GO Annotation Evidence References Source
involved in arachidonate metabolic process IDA
IDA: Inferred from direct assay
10660572 GOA
involved in epoxygenase P450 pathway IDA
IDA: Inferred from direct assay
9618440 GOA
involved in leukotriene metabolic process IDA
IDA: Inferred from direct assay
9799565 GOA
involved in long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
18433732 GOA
involved in positive regulation of icosanoid secretion IMP
IMP: Inferred from mutant phenotype
18391101 GOA
involved in pressure natriuresis IEP
IEP: Inferred from expression pattern
10660572 GOA
involved in renal water homeostasis IEP
IEP: Inferred from expression pattern
10660572 GOA
involved in sodium ion homeostasis IEP
IEP: Inferred from expression pattern
10660572 GOA
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
10660572 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
10660572 GOA
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
9618440 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP4A11 Protein Structure

p450

p450: Cytochrome P450 (52 - 502)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 519 a.a.
Protein Preferred Names Protein Names

cytochrome P450 4A11

  • 20-HETE synthase

CYP4A11 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82342 Cytochrome P450 4A/CYP4A11 Antibody (YA2087) WB, IHC-P, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Peroxisomal Acyl-Coa Oxidase Deficiency

  • Pseudoneonatal Adrenoleukodystrophy

  • Straight-Chain Acyl-Coa Oxidase Deficiency

  • Pseudoadrenoleukodystrophy

  • PSEUDO-NALD

  • Pseudo-Neonatal Adrenoleukodystrophy

  • Acyl-Coa Oxidase Deficiency

  • Peroxisomal Acyl-Coenzyme A Oxidase

  • Acyl-Coenzyme A Oxidase Deficiency

  • Adrenoleukodystrophy, Pseudoneonatal

  • Deficiency, Peroxisomal Acyl-Coa Oxidase
Bietti Crystalline Corneoretinal Dystrophy

  • BCD

  • Bietti Crystalline Dystrophy

  • Bietti Tapetoretinal Degeneration With Marginal Corneal Dystrophy

  • Bietti Crystalline Retinopathy

  • Bietti'S Crystalline Dystrophy

  • Crystalline Retinopathy

  • Dystrophy, Corneoretinal, Crystalline, Bietti
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Gliosarcoma

  • Glioblastoma With Sarcomatous Component

  • Sarcomatous Glioblastoma
Autosomal Recessive Congenital Ichthyosis

  • Lamellar Ichthyosis

  • Congenital Ichthyosiform Erythroderma

  • Li

  • Congenital Nonbullous Ichthyosiform Erythroderma

  • Arci

  • Congenital Lamellar Ichthyosis

  • Nonbullous Congenital Ichthyosiform Erythroderma

  • Cie

  • Congenital Non-Bullous Ichthyosiform Erythroderma

  • Erythrodermic Ichthyosis

  • Nbcie

  • Ncie

  • Non-Bullous Congenital Ichthyosiform Erythroderma

  • Collodion Baby

  • Ichthyosis, Lamellar

  • Non Bullous Congenital Ichthyosiform Erythroderma

  • Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

  • Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

  • Collodion Baby Syndrome

  • Ichthyoses, Lamellar

  • Nbie

  • Nonbullous Ichthyosiform Erythroderma

  • Classic Lamellar Ichthyosis

  • Ichthyosiform Erythroderma Nonbullous Congenital

  • Ichthyosiform Erythroderma Congenital

  • Ichthyosis, Congenital, Autosomal Recessive

  • Ichthyosiform Erythroderma, Congenital

  • Collodion Fetus

  • Non-Bullous Ichthyosiform Erythroderma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156876 20-HETE inhibitor-2 Inhibitor 99.17% Unkown
HY-151810 TP0472993 Inhibitor 98.22% Unkown
HY-151809 CYP4A11/CYP4F2-IN-1 Inhibitor 99.82% Unkown
HY-124084A SW203668 TFA Inhibitor 99.79% Unkown
HY-114606 SW208108 Inhibitor / Unkown
HY-124084 SW203668 Inhibitor / Unkown
HY-149770 CYP4A11/CYP4F2-IN-2 Inhibitor / Unkown
HY-RS03476 CYP4A11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03478 CYP4F11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W472509 11-HETE Activator / Unkown