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  4. Monoclonal Antibodies Recombinant Antibodies
  5. Cytochrome P450 4A/CYP4A11 Antibody (YA2087)

Cytochrome P450 4A/CYP4A11 Antibody (YA2087)

Cat. No.: HY-P82342
COA
SDS
User Guide for Antibodies Technical Support

Cytochrome P450 4A/CYP4A11 Antibody (YA2087) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 4A/CYP4A11.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

사이즈 가격 재고 수량
20 μL 해외재고보유
50 μL 해외재고보유
100 μL 해외재고보유
250 μL   견적 받기  
or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 제품 설명

제품 설명

Cytochrome P450 4A/CYP4A11 Antibody (YA2087) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 4A/CYP4A11.
Host

Rabbit
Clonality

Recombinant,Monoclonal
분자량
Predicted band size: 59 kDa;
Observed band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human Cytochrome P450 4A aa80-135/519.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:1000-1:2000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:100-1:200
IP
IP: Immunoprecipitation
1:50
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
선적

Shipping with blue ice.
Background
Function：A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:10553002, PubMed:10660572, PubMed:15611369, PubMed:1739747, PubMed:7679927, PubMed:8914854). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10553002, PubMed:10660572, PubMed:15611369, PubMed:1739747, PubMed:7679927, PubMed:8914854). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid (PubMed:10553002, PubMed:10660572). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PubMed:15611369, PubMed:1739747, PubMed:7679927, PubMed:8914854). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10620324, PubMed:10660572, PubMed:15611369). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PubMed:7679927). May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PubMed:18182499). Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer (PubMed:15145985). Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids (PubMed:18065749). Has little activity toward prostaglandins A1 and E1 (PubMed:7679927)
Subcellular Localization：Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane; Peripheral membrane protein
Expression：
Tissue_specificity:Expressed in liver (PubMed:7679927) . Expressed in S2 and S3 segments of proximal tubules in cortex and outer medulla of kidney (PubMed:10660572, PubMed:7679927)
Isoforms & Post-Translational Modification：Q02928 has 2 isomers: Q02928-1: 59348 Da (predicted); Q02928-2: 41052 Da (predicted).
Database

Entrez Gene: 1579 Human ; 50549 Rat

SwissProt: Q02928 Human ; P08516 Rat ; P20816 Rat

OMIM: 601310 Human

Research Field

Cardiovascular
Synonyms
cytochrome P450 family 4 subfamily A member 11; CP4Y; CYP4A2; CYP4AII; CYPIVA11
각종 서류
SDS (252 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

Cytochrome P450 4A/CYP4A11 Antibody (YA2087) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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상품명:
Cytochrome P450 4A/CYP4A11 Antibody (YA2087)
Cat. No.:
HY-P82342
수량:
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English - EN (252 KB)

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