GMDS - GDP-mannose 4,6-dehydratase Gene

Also Known as GMD; SDR3E1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2762

About GMDS

Cytogenetic location: 6p25.3 Genomic coordinates (GRCh38): 6:1,623,806-2,245,605 (from NCBI)

This gene has 10 transcripts (splice variants), 214 orthologues and 10 paralogues. Broad expression in colon (RPKM 6.8), stomach (RPKM 6.6) and 23 other tissues.

Summary

GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]

GMDS Products (2)

mRNA	Protein	Name
NM_001253846.2	NP_001240775.1	GDP-mannose 4,6 dehydratase isoform 2
NM_001500.4	NP_001491.1	GDP-mannose 4,6 dehydratase isoform 1

GMDS Protein Structure

Epimerase

0
100
200
300
372 a.a.

Protein Preferred Names	Protein Names
GDP-mannose 4,6 dehydratase	GDP-D-mannose dehydratase

GMDS Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GMDS	O60547	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	GMDS	O60547	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	25416956
Intra	GMDS	O60547	NTAQ1	Homo sapiens	Q96HA8	Y2H Prey Pooling	25416956
Intra	GMDS	O60547	GMDS	Homo sapiens	O60547	Validated Y2H	32296183
Intra	GMDS	O60547	GMDS	Homo sapiens	O60547	Y2H Array	31515488
Intra	GMDS	O60547	GMDS	Homo sapiens	O60547	Y2H Prey Pooling	32296183
Intra	GMDS	O60547	TAE1	Saccharomyces cerevisiae	P38340	Y2H Array	27107014
Intra	GMDS	O60547	TNKS	Homo sapiens	O95271	Anti Tag CoIP	33961781
Intra	GMDS	O60547	GMDS	Homo sapiens	O60547	Y2H Array	25416956
Intra	GMDS	O60547	TNKS	Homo sapiens	O95271	Anti Tag CoIP	28514442
Intra	GMDS	O60547	GMDS	Homo sapiens	O60547	Y2H Array	32296183
Intra	GMDS	O60547	TAE1	Saccharomyces cerevisiae	P38340	Y2H Pooling	27107014
Intra	GMDS	O60547	TNKS2	Homo sapiens	Q9H2K2	Anti Tag CoIP	28514442
Intra	GMDS	O60547	GMDS	Homo sapiens	O60547	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Congenital Disorder Of Glycosylation, Type Iic	CDG2C Congenital Disorder Of Glycosylation Type Iic Leukocyte Adhesion Deficiency Type Ii Cdg Iic Cdgiic Rambam-Hasharon Syndrome Leukocyte Adhesion Deficiency, Type Ii Lad2 Leukocyte Adhesion Deficiency 2 Cdg-Iic Congenital Disorder Of Glycosylation, Type 2c Rhs Cdg Syndrome Type Iic Lad-Ii Rambam Hasharon Syndrome Congenital Disorder Of Glycosylation 2c Glycosylation, Congenital Disorder Of, Type Iic
Partial Fetal Alcohol Syndrome
Non-Syndromic X-Linked Intellectual Disability Arx-Related	Arx-Related Intellectual Disability Mrxarx X-Linked Mental Retardation 29 X-Linked Mental Retardation 29 And Others X-Linked Mental Retardation 32 X-Linked Mental Retardation 33 X-Linked Mental Retardation 38 X-Linked Mental Retardation 43 X-Linked Mental Retardation 76 X-Linked Mental Retardation 87 X-Linked Mental Retardation With Or Without Seizures Arx-Related Mental Retardation, X-Linked, Type 29 And Others
Anterior Segment Dysgenesis 3	Iridogoniodysgenesis, Type 1 Irid1 Iridogoniodysgenesis Anomaly, Autosomal Dominant Igda ASGD3 Iris Hypoplasia With Glaucoma Glaucoma Iridogoniodysplasia, Familial Anterior Segment Dysgenesis 3, Multiple Subtypes Iridogoniodysgenesis Type 1 Glaucoma Iridogoniodysgenesia Igda Syndrome Iridogoniodysgenesis Anomaly
Traumatic Glaucoma	Glaucoma Associated With Ocular Trauma
Retinitis Pigmentosa 20	RP20 Retinitis Pigmentosa, Type 20
Axenfeld-Rieger Syndrome, Type 1	Axenfeld-Rieger Syndrome Type 1 RIEG1 Rieg Rgs Rieger Syndrome Type 1 Rieger Syndrome, Type 1 Axenfeld-Rieger Syndrome 1 Iridogoniodysgenesis With Somatic Anomalies
Myopathy, Centronuclear, 2	Myopathy, Centronuclear, Autosomal Recessive Autosomal Recessive Centronuclear Myopathy CNM2 Centronuclear Myopathy 2 Ar-Cnm Myotubular Myopathy, Autosomal Recessive Autosomal Recessive Myotubular Myopathy Centronuclear Myopathy Autosomal Recessive Myopathy, Centronuclear, Type 2
Glaucoma, Primary Open Angle	Glaucoma 1, Open Angle, E Primary Open Angle Glaucoma POAG Adult-Onset Primary Open Angle Glaucoma Chronic Simple Glaucoma GLC1E Primary Open Angle Glaucoma 1e Glaucoma, Open Angle, Primary
Primary Congenital Glaucoma
Axenfeld-Rieger Syndrome	Axenfeld Syndrome Rieger Syndrome Rieger Anomaly Axenfeld Anomaly Anomaly, Rieger'S Hagedoom Syndrome Rgs - Rieger Syndrome Rieger'S Anomaly Goniodysgenesis Hypodontia Iridogoniodysgenesis With Somatic Anomalies Ars Axenfeld And Rieger Anomaly Axra Axrs Rieger Eye Malformation Sequence
Peters-Plus Syndrome	Krause-Kivlin Syndrome Peters Plus Syndrome Peters Anomaly Irido-Corneo-Trabecular Dysgenesis PTRPLS Peters Anomaly With Short-Limb Dwarfism Peters Anomaly-Short Limb Dwarfism Syndrome Peters Anomaly With Short Limb Dwarfism Peters Congenital Glaucoma Krause-Van Schooneveld-Kivlin Syndrome Peters' Plus Syndrome Peters'-Plus Syndrome Anomaly Peters
Anterior Segment Dysgenesis	Anterior Segment Developmental Anomaly Anterior Segment Mesenchymal Dysgenesis Corneal Opacification And Other Ocular Anomalies Sclerocornea With Other Ocular Anomalies Asmd Asod Anterior Segment Ocular Dysgenesis Foxe3-Related Ocular Disorder Familial Ocular Anterior Segment Mesenchymal Dysgenesis Dysgenesis, Anterior Segment Irido-Corneal Dysgenesis Axenfeld-Rieger Syndrome, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N7389A	GDP-D-mannose disodium		99.97%	Unkown
HY-RS05515	GMDS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21350	Gmds Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27869	Gmds Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GMDS	RGD	RGD:1311008
Macaca mulatta	GMDS	VGNC	VGNC:73079
Mus musculus	GMDS	MGD	MGI:1891112
Canis familiaris	GMDS	VGNC	VGNC:58303
Felis catus	GMDS	VGNC	VGNC:62604
Bos taurus	GMDS	VGNC	VGNC:55901
Others	GMDS	NCBI