PHPT1 - phosphohistidine phosphatase 1 Gene

Also Known as PHP; PHP14; CGI-202; HSPC141; HEL-S-132P

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29085

About PHPT1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,849,409-136,851,024 (from NCBI)

This gene has 6 transcripts (splice variants) and 182 orthologues. Ubiquitous expression in heart (RPKM 26.6), prostate (RPKM 24.5) and 25 other tissues.

Summary

This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP Citrate Lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

PHPT1 Products (4)

mRNA Protein Name
NM_001135861.3 NP_001129333.1 14 kDa phosphohistidine phosphatase isoform 2
NM_001287342.2 NP_001274271.1 14 kDa phosphohistidine phosphatase isoform 4
NM_001287343.2 NP_001274272.1 14 kDa phosphohistidine phosphatase isoform 5
NM_014172.6 NP_054891.2 14 kDa phosphohistidine phosphatase isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
27924678 GOA
enables calcium channel inhibitor activity IDA
IDA: Inferred from direct assay
18796614 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
enables protein histidine phosphatase activity IDA
IDA: Inferred from direct assay
16219293 GOA
enables protein histidine phosphatase activity IMP
IMP: Inferred from mutant phenotype
18796614 GOA
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
18796614 GOA
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
27924678 GOA
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
19344975 GOA
involved in lamellipodium organization IDA
IDA: Inferred from direct assay
27924678 GOA
involved in negative regulation of ATP citrate synthase activity IDA
IDA: Inferred from direct assay
18656514 GOA
involved in negative regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18796614 GOA
involved in negative regulation of lyase activity IDA
IDA: Inferred from direct assay
20110805 GOA
involved in peptidyl-histidine dephosphorylation IDA
IDA: Inferred from direct assay
16219293 GOA
involved in positive regulation of cell motility IMP
IMP: Inferred from mutant phenotype
19344975 GOA
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
20501872 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
20501872 GOA
located in leading edge of lamellipodium IDA
IDA: Inferred from direct assay
27924678 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHPT1 Protein Structure

Ocnus

Ocnus: Janus/Ocnus family (Ocnus) (6 - 118)

  • 0
  • 100
  • 125 a.a.
Protein Preferred Names Protein Names

14 kDa phosphohistidine phosphatase

  • epididymis secretory sperm binding protein Li 132P

PHPT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PHPT1 Q9NRX4 KCNN4 Homo sapiens O15554
Anti Tag CoIP
18796614
Intra
PHPT1 Q9NRX4 ATXN1 Homo sapiens P54253
Y2H
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PHPT1 Proteins

Cat. No. Product Name Accession Purity
HY-P71769 PHPT1 Protein, Human (P.pastoris, His) Q9NRX4-1 (M1-Y125) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75975 PHPT1 Protein, Human (His) Q9NRX4-1 (A2-Y125) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hemolytic Disease Of Fetus And Newborn, Rh-Induced

  • Rh Deficiency Syndrome

  • Rh Disease

  • HDFNRH

  • Rh Fetomaternal Incompatibility

  • Rh-Null Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156029 IA1-8H2 Inhibitor / Unkown
HY-RS10453 PHPT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17838 Phpt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24306 Phpt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PHPT1 RGD RGD:1311355
Canis familiaris PHPT1 VGNC VGNC:44509
Felis catus PHPT1 VGNC VGNC:64153
Mus musculus PHPT1 MGD MGI:1922704
Bos taurus PHPT1 VGNC VGNC:32846
Others PHPT1 NCBI