2. Gene
  3. PHPT1 - phosphohistidine phosphatase 1 Gene

PHPT1 - phosphohistidine phosphatase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PHP; PHP14; CGI-202; HSPC141; HEL-S-132P

Gene ID: 29085 | Gene type: protein coding

About PHPT1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,849,409-136,851,024 (from NCBI)

This gene has 6 transcripts (splice variants) and 182 orthologues. Ubiquitous expression in heart (RPKM 26.6), prostate (RPKM 24.5) and 25 other tissues.

Summary

This gene encodes an Enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP Citrate Lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

PHPT1 Products(4)

mRNA Protein Name
NM_001135861.3 NP_001129333.1 14 kDa phosphohistidine phosphatase isoform 2
NM_001287342.2 NP_001274271.1 14 kDa phosphohistidine phosphatase isoform 4
NM_001287343.2 NP_001274272.1 14 kDa phosphohistidine phosphatase isoform 5
NM_014172.6 NP_054891.2 14 kDa phosphohistidine phosphatase isoform 3

PHPT1 Protein Structure

Ocnus

Ocnus: Janus/Ocnus family (Ocnus) (6 - 118)

  • 0
  • 100
  • 125 a.a.
Protein Preferred Names Protein Names

14 kDa phosphohistidine phosphatase

epididymis secretory sperm binding protein Li 132P

Recombinant PHPT1 Proteins

Cat. No. Product Name Accession Purity
HY-P71769 PHPT1 Protein, Human (P.pastoris, His) Q9NRX4 (1M-125Y) ≥95%
HY-P75975 PHPT1 Protein, Human (His) Q9NRX4 (A2-Y125) ≥95%

Related Diseases

Diseases Alias
Hemolytic Disease Of Fetus And Newborn, Rh-Induced

Rh Deficiency Syndrome

Rh Disease

HDFNRH

Rh Fetomaternal Incompatibility

Rh-Null Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156029 IA1-8H2 / Unkown
HY-RS10453 PHPT1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PHPT1 RGD RGD:1311355
Canis familiaris PHPT1 VGNC VGNC:44509
Felis catus PHPT1 VGNC VGNC:64153
Mus musculus PHPT1 MGD MGI:1922704
Bos taurus PHPT1 VGNC VGNC:32846
Others PHPT1 NCBI