Apc2 - APC regulator of WNT signaling pathway 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 299611

Summary

Predicted to enable beta-catenin binding activity; gamma-catenin binding activity; and microtubule binding activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of canonical Wnt signaling pathway; and negative regulation of microtubule depolymerization. Is active in postsynapse. Human ortholog(s) of this gene implicated in Sotos syndrome 3 and complex cortical dysplasia with Other brain malformations. Orthologous to human APC2 (APC regulator of Wnt signaling pathway 2). [provided by Alliance of Genome Resources, Apr 2022]

Apc2 Products (1)

mRNA Protein Name
NM_001106769.2 NP_001100239.2 adenomatous polyposis coli protein 2

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
is active in postsynapse IDA
IDA: Inferred from direct assay
21186356 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adenomatous polyposis coli protein 2

  • APC2, WNT signaling pathway regulator

  • adenomatosis polyposis coli 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119331 CFM-5 Inducer 99.48% Unkown
HY-103255 CFM-4 Inducer 98.85% Unkown
HY-116473 CFM-1 Antagonist / Unkown
HY-153538 AP-C2 Inhibitor / Unkown
HY-RS00680 ANAPC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00810 APC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13104 SLC25A23 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Apc2 NCBI NCBI:10297