Akr1c1 - aldo-keto reductase family 1, member C1 Gene

Also Known as Akr1c6; Hsd17b5

生物種: Rattus norvegicus

遺伝子タイプ: protein coding
遺伝子ID: 307092

Summary

Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity and testosterone 17-beta-dehydrogenase (NADP+) activity. Involved in response to estrogen and response to xenobiotic stimulus. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Apr 2022]

Akr1c1 Products (1)

mRNA Protein Name
NM_001033697.1 NP_001028869.1 aldo-keto reductase family 1, member C1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity IDA
IDA: Inferred from direct assay
16788056 RGD
enables testosterone 17-beta-dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
16788056 RGD
Biological Process GO Annotation Evidence 参考文献 由来
involved in response to estrogen IDA
IDA: Inferred from direct assay
16788056 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
16788056 RGD
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
18574251 RGD
located in nucleus IDA
IDA: Inferred from direct assay
18574251 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aldo-keto reductase family 1, member C1

  • 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

  • aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1

  • aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1

  • 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

  • aldo-keto reduc

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-114009 AKR1C1-IN-1 Inhibitor 99.87% Unkown
HY-118819 5-Bromo-3-phenyl salicylic acid Inhibitor 98.00% Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Akr1c1 NCBI NCBI:1645